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Tbio
SLC30A7
Zinc transporter 7

Protein Summary
Description
Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity). Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357650
  • ENSP00000350278
  • ENSG00000162695
  • ENST00000370112
  • ENSP00000359130

Symbol
  • ZNT7
  • ZNTL2
  • ZNT7
  • ZnT-7
  • ZnTL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
virus perturbation
0.92
histone modification site profile
0.9
microRNA
0.9
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.35   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.35   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
ST3GAL1
Tchem
Family:  Enzyme
Novelty:  0.01236776
p_int:  0.944470756
p_ni:  0.055529244
Score:  0.187
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.885740429
p_ni:  0.114259571
Score:  0.311
Data Source:  BioPlex,STRINGDB
C12orf49
Tdark
Novelty:  0.56030929
p_int:  0.881328503
p_ni:  0.118671497
Score:  0.188
Data Source:  BioPlex,STRINGDB
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.828744764
p_ni:  0.171255236
Data Source:  BioPlex
SLC34A2
Tchem
Family:  Transporter
Novelty:  0.00601743
p_int:  0.82277922
p_ni:  0.17722078
Score:  0.194
Data Source:  BioPlex,STRINGDB
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.789891622
p_ni:  0.210108378
Score:  0.161
Data Source:  BioPlex,STRINGDB
SLC39A7
Tbio
Family:  Transporter
Novelty:  0.01746862
Score:  0.889
Data Source:  STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
Score:  0.861
Data Source:  STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
Score:  0.849
Data Source:  STRINGDB
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Insulin processing (R-HSA-264876)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insulin processing
Reactome
Metabolism of proteins
Reactome
Metal ion SLC transporters
Reactome
Peptide hormone metabolism
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Insulin processing
Metabolism of proteins
Metal ion SLC transporters
Peptide hormone metabolism
SLC-mediated transmembrane transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
55.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 7
VGNC:8111
457061
Macaque
solute carrier family 30 member 7
712125
Mouse
MGI:1913750
66500
Rat
RGD:1307873
310801
Dog
solute carrier family 30 member 7
VGNC:46352
479924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 30 member 7
Macaque
solute carrier family 30 member 7
Mouse
Rat
Dog
solute carrier family 30 member 7
Publication Statistics
PubMed Score 35.35
PubMed score by year
PubTator Score 7.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title