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Tbio
MYO3A
Myosin-IIIa

Protein Summary
Description
Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity). The protein encoded by this gene belongs to the myosin superfamily. Myosins are actin-dependent motor proteins and are categorized into conventional myosins (class II) and unconventional myosins (classes I and III through XV) based on their variable C-terminal cargo-binding domains. Class III myosins, such as this one, have a kinase do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265944
  • ENSP00000265944
  • ENSG00000095777
  • ENST00000376302
  • ENSP00000365479
  • ENST00000642920
  • ENSP00000495965

Symbol
  • DFNB30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
pathway
0.63
cell type or tissue
0.59
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.84   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.84   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cytoskeletal regulation by Rho GTPase
PathwayCommons: panther
Inflammation mediated by chemokine and cytokine signaling pathway
PathwayCommons: panther
Nicotinic acetylcholine receptor signaling pathway
Name
Explore in Pharos
Explore in Source
Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Gene Ontology Terms (20)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (100)
1 – 10 of 100
MYL12B
Tbio
Novelty: 0.00999083
p_int: 0.999999914
p_ni: 3.1e-8
p_wrong: 5.5e-8
Score: 0.285
Data Source: BioPlex,STRINGDB
TNNC1
Tclin
Novelty: 0.03535727
p_int: 0.999999865
p_ni: 8.8e-8
p_wrong: 4.7e-8
Score: 0.273
Data Source: BioPlex,STRINGDB
MORN4
Tdark
Novelty: 0.22826325
p_int: 0.887864336
p_ni: 0.000152273
p_wrong: 0.111983391
Score: 0.862
Data Source: BioPlex,STRINGDB
ESPN
Tbio
Novelty: 0.0035928
Score: 0.963
Data Source: STRINGDB
MYO6
Tbio
Novelty: 0.01073438
Score: 0.922
Data Source: STRINGDB
MYO1A
Tbio
Novelty: 0.00942771
Score: 0.918
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.917
Data Source: STRINGDB
MYO1C
Tbio
Novelty: 0.00967011
Score: 0.917
Data Source: STRINGDB
PDLIM4
Tbio
Novelty: 0.01308013
Score: 0.915
Data Source: STRINGDB
CD2AP
Tbio
Novelty: 0.00603034
Score: 0.904
Data Source: STRINGDB
Publication Statistics
PubMed Score  30.84

PubMed score by year
PubTator Score  22.86

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer