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Tbio
APPL2
DCC-interacting protein 13-beta

Protein Summary
Description
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction. The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258530
  • ENSP00000258530
  • ENSG00000136044
  • ENST00000539978
  • ENSP00000444472
  • ENST00000551662
  • ENSP00000446917

Symbol
  • DIP13B
  • DIP13B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
cell type or tissue
0.71
interacting protein
0.71
cellular component
0.65
gene perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.11   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
1
2
52.4
total cholesterol measurement
1
1
1
52
self reported educational attainment
1
1
1
39.6
mathematical ability
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
52.4
total cholesterol measurement
1
52
self reported educational attainment
1
39.6
mathematical ability
1
27.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
VGNC:8593
452197
Mouse
MGI:2384914
216190
Rat
RGD:1563028
362860
Dog
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
VGNC:38013
481297
Horse
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
VGNC:15431
100068170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Mouse
Rat
Dog
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Horse
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NEU8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (30)
1 – 10 of 30
APPL1
Tbio
Novelty:  0.00973424
p_int:  1
Score:  0.531
Data Source:  BioPlex,STRINGDB
RABL2B
Tdark
Family:  Enzyme
Novelty:  0.16730643
Score:  0.938
Data Source:  STRINGDB
RABL2A
Tbio
Family:  Enzyme
Novelty:  0.09940618
Score:  0.917
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.715
Data Source:  STRINGDB
ALG12
Tbio
Family:  Enzyme
Novelty:  0.03785588
Score:  0.641
Data Source:  STRINGDB
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
Score:  0.639
Data Source:  STRINGDB
RAB22A
Tbio
Family:  Enzyme
Novelty:  0.02344687
Score:  0.631
Data Source:  STRINGDB
ADIPOR1
Tbio
Novelty:  0.00273623
Score:  0.583
Data Source:  STRINGDB
ADIPOR2
Tbio
Novelty:  0.00330423
Score:  0.573
Data Source:  STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.568
Data Source:  STRINGDB
Publication Statistics
PubMed Score  6.11

PubMed score by year
PubTator Score  13.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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