Tchem TRPV3 Transient receptor potential cation channel subfamily V member 3

Protein Summary

Description

Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q8NET8
• Q8NDW7
• Q8NET9
• Q8NFH2
• TrpV3

Gene Name

• TRPV3

Ensembl ID

• ENST00000301365
• ENSP00000301365
• ENSG00000167723
• ENST00000572519
• ENSP00000460215
• ENST00000576742
• ENSP00000461518

Symbol

• OLMS
• VRL3
• FNEPPK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.76
protein domain	0.73
cell line	0.6
molecular function	0.6
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily V Member 3

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Trpv Subfamily / Trpv3 Sub-subfamily / Transient Receptor Potential Cation Channel Subfamily V Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.69   (req: < 5)

Gene RIFs: 67   (req: <= 3)

Antibodies: 384   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.69   (req: >= 5)

Gene RIFs: 67   (req: > 3)

Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 245

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2