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Tbio
DEFB124
Beta-defensin 124

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. The encoded protein may serve to enhance innate immunity in the prostate. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317676
  • ENSP00000326309
  • ENSG00000180383

Symbol
  • DEFB24
  • DEFB-24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.4
cell line
0.39
cellular component
0.37
biological term
0.33
pathway
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
DEFB135
Tdark
Novelty:  2.04107063
Score:  0.979
Data Source:  STRINGDB
DEFB125
Tdark
Novelty:  0.69005738
Score:  0.978
Data Source:  STRINGDB
DEFB128
Tbio
Novelty:  0.30093411
Score:  0.977
Data Source:  STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
Score:  0.974
Data Source:  STRINGDB
DEFB134
Tdark
Novelty:  0.94544485
Score:  0.961
Data Source:  STRINGDB
DEFB123
Tdark
Novelty:  0.17722275
Score:  0.959
Data Source:  STRINGDB
DEFB113
Tdark
Novelty:  0.54376643
Score:  0.955
Data Source:  STRINGDB
DEFB121
Tdark
Novelty:  2.72797456
Score:  0.955
Data Source:  STRINGDB
DEFB114
Tbio
Novelty:  0.22206668
Score:  0.949
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.948
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
47.7
apolipoprotein A 1 measurement
1
1
1
46.9
1
1
0
1.1
36.9
alkaline phosphatase measurement
1
1
1
32.6
eosinophil count
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
47.7
apolipoprotein A 1 measurement
1
46.9
0
1.1
36.9
alkaline phosphatase measurement
1
32.6
eosinophil count
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 124
VGNC:6092
742102
Macaque
defensin beta 124
713413
Mouse
MGI:3651158
654459
Rat
RGD:1564765
641644
Dog
defensin beta 124
VGNC:39878
100135058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 124
Macaque
defensin beta 124
Mouse
Rat
Dog
defensin beta 124
Publication Statistics
PubMed Score 1.18
PubMed score by year
PubTator Score 1.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title