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Tbio
DEFB124
Beta-defensin 124

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the host immunologic response to invading microorganisms. This antimicrobial protein is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20q11.1. The encoded protein may serve to enhance innate immunity in the prostate. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317676
  • ENSP00000326309
  • ENSG00000180383

Symbol
  • DEFB24
  • DEFB-24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.4
cell line
0.39
cellular component
0.37
biological term
0.33
pathway
0.32


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 124
VGNC:6092
742102
Macaque
defensin beta 124
713413
Mouse
MGI:3651158
654459
Rat
RGD:1564765
641644
Dog
defensin beta 124
VGNC:39878
100135058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 124
Macaque
defensin beta 124
Mouse
Rat
Dog
defensin beta 124
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (41)
1 – 10 of 41
DEFB135
Tdark
Novelty: 2.04107063
Score: 0.979
Data Source: STRINGDB
DEFB125
Tdark
Novelty: 0.69005738
Score: 0.978
Data Source: STRINGDB
DEFB128
Tbio
Novelty: 0.30093411
Score: 0.977
Data Source: STRINGDB
DEFB127
Tbio
Novelty: 0.18126756
Score: 0.974
Data Source: STRINGDB
DEFB134
Tdark
Novelty: 0.94544485
Score: 0.961
Data Source: STRINGDB
DEFB123
Tdark
Novelty: 0.17722275
Score: 0.959
Data Source: STRINGDB
DEFB113
Tdark
Novelty: 0.54376643
Score: 0.955
Data Source: STRINGDB
DEFB121
Tdark
Novelty: 2.72797456
Score: 0.955
Data Source: STRINGDB
DEFB114
Tbio
Novelty: 0.22206668
Score: 0.949
Data Source: STRINGDB
DEFB129
Tdark
Novelty: 0.26809608
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.18

PubMed score by year
PubTator Score  1.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer