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Tbio
LFNG
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Protein Summary
Description
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity). This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222725
  • ENSP00000222725
  • ENSG00000106003
  • ENST00000338732
  • ENSP00000343095
  • ENST00000359574
  • ENSP00000352579
  • ENST00000402045
  • ENSP00000384786
  • ENST00000402506
  • ENSP00000385764

Symbol
  • SCDO3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
gene perturbation
0.92
transcription factor
0.86
transcription factor perturbation
0.68
cellular component
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.58   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.58   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
59.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
59.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
VGNC:14035
472272
Macaque
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
100428736
Mouse
MGI:1095413
16848
Rat
RGD:620587
170905
Dog
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
VGNC:42645
489891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Macaque
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Mouse
Rat
Dog
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NES3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Defective LFNG causes SCDO3 (R-HSA-5083630)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective LFNG causes SCDO3
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Pre-NOTCH Expression and Processing
Name
Explore in Pharos
Explore in Source
Defective LFNG causes SCDO3
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Pre-NOTCH Expression and Processing
Protein-Protein Interactions (56)
1 – 10 of 56
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.986
Data Source: Reactome,STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.976
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.965
Data Source: STRINGDB
NOTCH4
Tchem
Novelty: 0.00471643
Score: 0.941
Data Source: STRINGDB
MESP2
Tbio
Family: TF
Novelty: 0.02601024
Score: 0.84
Data Source: STRINGDB
HES7
Tbio
Family: TF
Novelty: 0.02014919
Score: 0.839
Data Source: STRINGDB
MFNG
Tbio
Family: Enzyme
Novelty: 0.09624431
Score: 0.814
Data Source: STRINGDB
RFNG
Tdark
Family: Enzyme
Novelty: 0.1966578
Score: 0.81
Data Source: STRINGDB
JAG1
Tbio
Novelty: 0.00107618
Score: 0.767
Data Source: STRINGDB
DLL1
Tbio
Novelty: 0.00150384
Score: 0.713
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.58

PubMed score by year
PubTator Score  23.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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