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Tbio
ACVR1C
Activin receptor type-1C

Protein Summary
Description
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243349
  • ENSP00000243349
  • ENSG00000123612
  • ENST00000335450
  • ENSP00000335178
  • ENST00000348328
  • ENSP00000335139
  • ENST00000409680
  • ENSP00000387168

Symbol
  • ALK7
  • ALK7
  • ACVRLK7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.92
protein domain
0.92
microRNA
0.91
gene perturbation
0.76


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.68   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
2
6
94
waist-hip ratio
2
1
2
78
1
1
1
61.6
birth weight
1
1
1
58
total cholesterol measurement
1
1
1
40.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
94
waist-hip ratio
2
78
1
61.6
birth weight
1
58
total cholesterol measurement
1
40.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 1C
VGNC:58
470564
Macaque
activin A receptor type 1C
697826
Mouse
MGI:2661081
269275
Rat
RGD:621789
245921
Dog
activin A receptor type 1C
VGNC:37563
488361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
activin A receptor type 1C
Macaque
activin A receptor type 1C
Mouse
Rat
Dog
activin A receptor type 1C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NER5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signal Transduction
Reactome
Signaling by Activin
Reactome
Signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signal Transduction
Signaling by Activin
Signaling by NODAL
Gene Ontology Terms (29)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
ACVR1B
Tchem
Family: Kinase
Novelty: 0.00633595
p_int: 0.999995449
p_ni: 0.000004551
Score: 0.905
Data Source: BioPlex,STRINGDB
DNAJB5
Tbio
Novelty: 0.20703358
p_int: 0.99394147
p_ni: 0.006020145
p_wrong: 0.000038385
Data Source: BioPlex
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
p_int: 0.987006788
p_ni: 0.012993212
Data Source: BioPlex
C1orf43
Tbio
Novelty: 0.13587458
p_int: 0.940047462
p_ni: 0.05995217
p_wrong: 3.68e-7
Data Source: BioPlex
TYW1
Tbio
Family: Enzyme
Novelty: 0.05117274
p_int: 0.931179281
p_ni: 0.068820719
Data Source: BioPlex
SUN2
Tbio
Novelty: 0.01387591
p_int: 0.927986531
p_ni: 0.071985971
p_wrong: 0.000027498
Data Source: BioPlex
HMGCR
Tclin
Family: Enzyme
Novelty: 0.00046789
p_int: 0.907917318
p_ni: 0.092082682
Data Source: BioPlex
DNAJC18
Tdark
Novelty: 1.38573997
p_int: 0.89309588
p_ni: 0.105254352
p_wrong: 0.001649768
Data Source: BioPlex
ATP2A3
Tbio
Family: Transporter
Novelty: 0.0090982
p_int: 0.84370071
p_ni: 0.15629929
Data Source: BioPlex
DAGLB
Tchem
Family: Enzyme
Novelty: 0.03269024
p_int: 0.83382578
p_ni: 0.166151073
p_wrong: 0.000023147
Data Source: BioPlex
Publication Statistics
PubMed Score  60.68

PubMed score by year
PubTator Score  29.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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