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Tclin
TRPV1
Transient receptor potential cation channel subfamily V member 1

Protein Summary
Description
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399756
  • ENSP00000382659
  • ENSG00000196689
  • ENST00000399759
  • ENSP00000382661
  • ENST00000571088
  • ENSP00000461007
  • ENST00000572705
  • ENSP00000459962

Symbol
  • VR1
  • VR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
1
ligand (chemical)
0.97
biological term
0.94
cellular component
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5651.39   (req: < 5)
Gene RIFs: 311   (req: <= 3)
Antibodies: 493   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5651.39   (req: >= 5)
Gene RIFs: 311   (req: > 3)
Antibodies: 493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1873
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 1
VGNC:14210
750493
Macaque
transient receptor potential cation channel subfamily V member 1
721455
Mouse
MGI:1341787
193034
Rat
RGD:628841
83810
Dog
transient receptor potential cation channel subfamily V member 1
VGNC:47882
445457
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily V member 1
Macaque
transient receptor potential cation channel subfamily V member 1
Mouse
Rat
Dog
transient receptor potential cation channel subfamily V member 1
Pathways (62)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Gene Ontology Terms (60)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (211)
1 – 10 of 211
TRPA1
Tclin
Family: IC
Novelty: 0.00093648
Score: 0.963
Data Source: STRINGDB
TRPM8
Tclin
Family: IC
Novelty: 0.00153949
Score: 0.954
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.944
Data Source: STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.929
Data Source: STRINGDB
TAC1
Tbio
Novelty: 0.00006575
Score: 0.905
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.888
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.888
Data Source: STRINGDB
FAAH
Tchem
Family: Enzyme
Novelty: 0.00162361
Score: 0.867
Data Source: STRINGDB
GPR55
Tclin
Family: GPCR
Novelty: 0.00428199
Score: 0.863
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.861
Data Source: STRINGDB
Publication Statistics
PubMed Score  5651.39

PubMed score by year
PubTator Score  1622.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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