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Tbio
DNAAF1
Dynein assembly factor 1, axonemal

Protein Summary
Description
Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli. The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378553
  • ENSP00000367815
  • ENSG00000154099
  • ENST00000563093
  • ENSP00000457373

Symbol
  • LRRC50
  • swt
  • ODA7
  • CILD13
  • LRRC50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
histone modification site profile
0.63
cell line
0.6
tissue sample
0.57
transcription factor binding site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.6   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (56)
1 – 10 of 56
DNALI1
Tbio
Novelty: 0.13865981
Score: 0.904
Data Source: STRINGDB
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.902
Data Source: STRINGDB
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.852
Data Source: STRINGDB
ZMYND10
Tbio
Novelty: 0.05524895
Score: 0.846
Data Source: STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
Score: 0.818
Data Source: STRINGDB
XPNPEP3
Tbio
Family: Enzyme
Novelty: 0.02209842
Score: 0.796
Data Source: STRINGDB
DNAAF3
Tbio
Novelty: 0.06768631
Score: 0.791
Data Source: STRINGDB
DAW1
Tdark
Novelty: 0.08712536
Score: 0.787
Data Source: STRINGDB
CCDC63
Tbio
Novelty: 0.11520913
Score: 0.731
Data Source: STRINGDB
RSPH4A
Tbio
Novelty: 0.07992083
Score: 0.726
Data Source: STRINGDB
Publication Statistics
PubMed Score  26.60

PubMed score by year
PubTator Score  11.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer