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Tbio
AGBL3
Cytosolic carboxypeptidase 3

Protein Summary
Description
Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. Isoform 2: Metallocarboxypeptidase that mediates tubulin deglutamylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275763
  • ENSP00000275763
  • ENSG00000146856
  • ENST00000436302
  • ENSP00000388275

Symbol
  • CCP3
  • CCP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
histone modification site profile
0.81
gene perturbation
0.78
kinase perturbation
0.66
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.22   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.22   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
LIAT1
Tdark
Novelty:  0.7167986
p_int:  0.99371049
p_ni:  1e-9
p_wrong:  0.006289509
Data Source:  BioPlex
CLIC3
Tbio
Family:  IC
Novelty:  0.07268934
p_int:  0.94015483
p_ni:  0.059845169
Data Source:  BioPlex
CXADR
Tbio
Novelty:  0.00269793
Score:  0.643
Data Source:  STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
Score:  0.617
Data Source:  STRINGDB
CD46
Tbio
Novelty:  0.00098341
Score:  0.574
Data Source:  STRINGDB
LRGUK
Tdark
Family:  Enzyme
Novelty:  0.42433819
Score:  0.568
Data Source:  STRINGDB
KLHDC1
Tbio
Novelty:  1.2348626
Score:  0.544
Data Source:  STRINGDB
ARMC9
Tbio
Novelty:  0.08891767
Score:  0.53
Data Source:  STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
Score:  0.529
Data Source:  STRINGDB
C18orf63
Tdark
Novelty:  1.94805195
Score:  0.511
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
70.9
aspartate aminotransferase measurement
1
1
0
7.5
59.9
hemoglobin measurement
2
2
2
54.3
serum alanine aminotransferase measurement
2
1
1
6.3
52.7
monocyte percentage of leukocytes
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
70.9
aspartate aminotransferase measurement
0
7.5
59.9
hemoglobin measurement
2
54.3
serum alanine aminotransferase measurement
1
6.3
52.7
monocyte percentage of leukocytes
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP/GTP binding protein like 3
VGNC:13626
463747
Macaque
cytosolic carboxypeptidase 3
707147
Mouse
MGI:1923473
76223
Rat
RGD:1561995
500076
Dog
ATP/GTP binding protein like 3
VGNC:37697
475504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP/GTP binding protein like 3
Macaque
cytosolic carboxypeptidase 3
Mouse
Rat
Dog
ATP/GTP binding protein like 3
Publication Statistics
PubMed Score 62.22
PubMed score by year
PubTator Score 35.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title