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Tdark
ZNF680
Zinc finger protein 680

Protein Summary
Description
May be involved in transcriptional regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309683
  • ENSP00000309330
  • ENSG00000173041
  • ENST00000447137
  • ENSP00000393506
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
1
cell type or tissue
0.68
tissue sample
0.66
protein domain
0.58
cell line
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
1
2
77.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
77.5
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 680
VGNC:4580
472392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 680
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NEM1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (14)
1 – 10 of 14
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.904
Data Source: STRINGDB
KIAA1841
Tdark
Novelty: 1.50148602
Score: 0.567
Data Source: STRINGDB
MAP1S
Tbio
Novelty: 0.02643414
Score: 0.552
Data Source: STRINGDB
POMK
Tbio
Family: Kinase
Novelty: 0.09340344
Score: 0.519
Data Source: STRINGDB
HGSNAT
Tbio
Family: Enzyme
Novelty: 0.03264423
Score: 0.511
Data Source: STRINGDB
UBXN7
Tbio
Novelty: 0.07437638
Score: 0.5
Data Source: STRINGDB
FSD1
Tbio
Novelty: 0.03452477
Score: 0.486
Data Source: STRINGDB
COMMD6
Tbio
Novelty: 0.11854363
Score: 0.477
Data Source: STRINGDB
FCRL6
Tbio
Novelty: 0.19257954
Score: 0.471
Data Source: STRINGDB
ALPK2
Tbio
Family: Kinase
Novelty: 0.0442897
Score: 0.453
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.13

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer