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Tbio
MCPH1
Microcephalin

Protein Summary
Description
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344683
  • ENSP00000342924
  • ENSG00000147316
  • ENST00000519480
  • ENSP00000430962
  • ENST00000522905
  • ENSP00000430768
  • ENST00000643429
  • ENSP00000496505
  • ENSG00000285262
  • ENST00000646478
  • ENSP00000494584
  • ENST00000647051
  • ENSP00000493874

Symbol
  • MCT
  • BRIT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
histone modification site profile
0.89
transcription factor perturbation
0.88
transcription factor binding site profile
0.87
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.64   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.64   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prophase Chromosomes
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prophase Chromosomes
M Phase
Mitotic Prophase
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (98)
1 – 10 of 98
CRACR2A
Tchem
Novelty: 0.14676762
p_int: 0.793967214
p_ni: 0.000002734
p_wrong: 0.206030052
Score: 0.685
Data Source: BioPlex,STRINGDB
NCAPG2
Tbio
Novelty: 0.13940152
Score: 0.956
Data Source: STRINGDB
NCAPD3
Tbio
Novelty: 0.05613069
Score: 0.95
Data Source: STRINGDB
NCAPH2
Tbio
Novelty: 0.16162826
Score: 0.949
Data Source: STRINGDB
SMC4
Tbio
Novelty: 0.02543279
Score: 0.939
Data Source: STRINGDB
SMC2
Tbio
Novelty: 0.13883394
Score: 0.936
Data Source: STRINGDB
CENPJ
Tbio
Novelty: 0.01558222
Score: 0.92
Data Source: STRINGDB
CDK5RAP2
Tbio
Novelty: 0.01336212
Score: 0.918
Data Source: STRINGDB
WDR62
Tbio
Novelty: 0.02793407
Score: 0.918
Data Source: STRINGDB
SET
Tbio
Novelty: 0.00254126
Score: 0.901
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  122.64

PubMed score by year
PubTator Score  112.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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