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Tbio
MCPH1
Microcephalin

Protein Summary
Description
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344683
  • ENSP00000342924
  • ENSG00000147316
  • ENST00000519480
  • ENSP00000430962
  • ENST00000522905
  • ENSP00000430768
  • ENST00000643429
  • ENSP00000496505
  • ENSG00000285262
  • ENST00000646478
  • ENSP00000494584
  • ENST00000647051
  • ENSP00000493874

Symbol
  • MCT
  • BRIT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
histone modification site profile
0.89
transcription factor perturbation
0.88
transcription factor binding site profile
0.87
trait
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.16   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 325   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.16   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 325   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
2
2
1
5.8
76.2
serum alanine aminotransferase measurement
2
2
1
5.8
76.2
carotid artery intima media thickness
2
3
4
75.7
carotid artery intima media thickness
2
3
4
75.7
heel bone mineral density
2
2
3
71.4
Items per page:
1 – 5 of 26
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum alanine aminotransferase measurement
1
5.8
76.2
serum alanine aminotransferase measurement
1
5.8
76.2
carotid artery intima media thickness
4
75.7
carotid artery intima media thickness
4
75.7
heel bone mineral density
3
71.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microcephalin 1
VGNC:850
449589
Macaque
microcephalin 1
106999655
Mouse
MGI:2443308
244329
Rat
RGD:1560642
306594
Dog
microcephalin 1
VGNC:43091
442960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microcephalin 1
Macaque
microcephalin 1
Mouse
Rat
Dog
microcephalin 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NEM0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prophase Chromosomes
Reactome
M Phase
Reactome
Mitotic Prophase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prophase Chromosomes
M Phase
Mitotic Prophase
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (98)
1 – 10 of 98
CRACR2A
Tchem
Novelty:  0.11259702
p_int:  0.793967214
p_ni:  0.000002734
p_wrong:  0.206030052
Score:  0.685
Data Source:  BioPlex,STRINGDB
NCAPG2
Tbio
Novelty:  0.07545554
Score:  0.956
Data Source:  STRINGDB
NCAPD3
Tbio
Novelty:  0.02819003
Score:  0.95
Data Source:  STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
Score:  0.949
Data Source:  STRINGDB
SMC4
Tbio
Novelty:  0.01529151
Score:  0.939
Data Source:  STRINGDB
SMC2
Tchem
Novelty:  0.06898543
Score:  0.936
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.92
Data Source:  STRINGDB
CDK5RAP2
Tbio
Novelty:  0.00956263
Score:  0.918
Data Source:  STRINGDB
WDR62
Tbio
Novelty:  0.02611137
Score:  0.918
Data Source:  STRINGDB
SET
Tbio
Novelty:  0.01012327
Score:  0.901
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  138.16

PubMed score by year
PubTator Score  112.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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