Protein Classes
Protein Summary
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
- ENST00000344683
- ENSP00000342924
- ENSG00000147316
- ENST00000519480
- ENSP00000430962
- ENST00000522905
- ENSP00000430768
- ENST00000643429
- ENSP00000496505
- ENSG00000285262
- ENST00000646478
- ENSP00000494584
- ENST00000647051
- ENSP00000493874
- MCT
- BRIT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
histone modification site profile | 0.89 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.87 | ||
trait | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 122.64 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 325 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 122.64 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 325 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (16)
Reactome (5)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Condensation of Prophase Chromosomes | ||||
Reactome | M Phase | ||||
Reactome | Mitotic Prophase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Condensation of Prophase Chromosomes | ||||
M Phase | ||||
Mitotic Prophase | ||||
Gene Ontology Terms (15)
Functions (1)
Components (3)
Processes (11)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Protein-Protein Interactions (98)
1 – 10 of 98
CRACR2A
Novelty: 0.14676762
p_int: 0.793967214
p_ni: 0.000002734
p_wrong: 0.206030052
Score: 0.685
Data Source: BioPlex,STRINGDB
NCAPG2
Novelty: 0.13940152
Score: 0.956
Data Source: STRINGDB
NCAPD3
Novelty: 0.05613069
Score: 0.95
Data Source: STRINGDB
NCAPH2
Novelty: 0.16162826
Score: 0.949
Data Source: STRINGDB
SMC4
Novelty: 0.02543279
Score: 0.939
Data Source: STRINGDB
SMC2
Novelty: 0.13883394
Score: 0.936
Data Source: STRINGDB
CENPJ
Novelty: 0.01558222
Score: 0.92
Data Source: STRINGDB
CDK5RAP2
Novelty: 0.01336212
Score: 0.918
Data Source: STRINGDB
WDR62
Novelty: 0.02793407
Score: 0.918
Data Source: STRINGDB
SET
Novelty: 0.00254126
Score: 0.901
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 122.64
PubMed score by year
PubTator Score 112.59
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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