Protein Summary
Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex. This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]
- ENST00000344683
- ENSP00000342924
- ENSG00000147316
- ENST00000519480
- ENSP00000430962
- ENST00000522905
- ENSP00000430768
- ENST00000643429
- ENSP00000496505
- ENSG00000285262
- ENST00000646478
- ENSP00000494584
- ENST00000647051
- ENSP00000493874
- MCT
- BRIT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
histone modification site profile | 0.89 | ||
transcription factor perturbation | 0.88 | ||
transcription factor binding site profile | 0.87 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 138.16 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 325 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 138.16 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 325 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (98)
CRACR2A
Novelty: 0.11259702
p_int: 0.793967214
p_ni: 0.000002734
p_wrong: 0.206030052
Score: 0.685
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (5)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Condensation of Prophase Chromosomes | ||||
Reactome | M Phase | ||||
Reactome | Mitotic Prophase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Condensation of Prophase Chromosomes | ||||
M Phase | ||||
Mitotic Prophase | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (1)
Components (3)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations (null)
GWAS Traits (26)
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
serum alanine aminotransferase measurement | 2 | 2 | 1 | 5.8 | 76.2 | |||||
serum alanine aminotransferase measurement | 2 | 2 | 1 | 5.8 | 76.2 | |||||
carotid artery intima media thickness | 2 | 3 | 4 | 75.7 | ||||||
carotid artery intima media thickness | 2 | 3 | 4 | 75.7 | ||||||
heel bone mineral density | 2 | 2 | 3 | 71.4 | ||||||
Items per page:
1 – 5 of 26
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum alanine aminotransferase measurement | 1 | 5.8 | 76.2 | ||||
serum alanine aminotransferase measurement | 1 | 5.8 | 76.2 | ||||
carotid artery intima media thickness | 4 | 75.7 | |||||
carotid artery intima media thickness | 4 | 75.7 | |||||
heel bone mineral density | 3 | 71.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | microcephalin 1 | VGNC:850 | 449589 | |||||
Macaque | microcephalin 1 | 106999655 | ||||||
Mouse | MGI:2443308 | 244329 | ||||||
Rat | RGD:1560642 | 306594 | ||||||
Dog | microcephalin 1 | VGNC:43091 | 442960 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | microcephalin 1 | |||||
Macaque | microcephalin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | microcephalin 1 | |||||
Publication Statistics
PubMed Score 138.16
PubMed score by year
PubTator Score 112.59
PubTator score by year
Related Publications
Text Mined References (112)
GeneRif Annotations (67)
Items per page:
0 of 0
PMID | Year | Title |
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