You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NGDN
Neuroguidin

Protein Summary
Description
Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397154
  • ENSP00000380340
  • ENSG00000129460
  • ENST00000408901
  • ENSP00000386134

Symbol
  • C14orf120
  • NGD
  • LCP5
  • CANu1
  • lpd-2
  • C14orf120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.94
kinase perturbation
0.93
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (281)
NOL10
Tdark
Novelty:  0.27358884
p_int:  0.999988763
p_ni:  0.000011234
p_wrong:  3e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.961164377
p_ni:  0.038835622
p_wrong:  1e-9
Score:  0.184
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.954318935
p_ni:  0.045662945
p_wrong:  0.000018121
Score:  0.209
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.951029521
p_ni:  0.048969568
p_wrong:  9.11e-7
Data Source:  BioPlex
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.929377893
p_ni:  0.070622096
p_wrong:  1.1e-8
Score:  0.485
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.910315545
p_ni:  0.089684411
p_wrong:  4.4e-8
Score:  0.178
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.878924914
p_ni:  0.121075004
p_wrong:  8.2e-8
Score:  0.563
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.876697621
p_ni:  0.123302365
p_wrong:  1.5e-8
Score:  0.468
Data Source:  BioPlex,STRINGDB
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.848167247
p_ni:  0.151832669
p_wrong:  8.5e-8
Data Source:  BioPlex
RNF151
Tdark
Novelty:  2.0077961
p_int:  0.815183609
p_ni:  0.184813793
p_wrong:  0.000002598
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
2
1
61
5.3
83.4
heart rate
2
1
1
5.3
83.3
2
2
0
1.1
74.6
P wave terminal force measurement
1
1
0
133.5
74.5
resting heart rate
1
2
0
7.6
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
61
5.3
83.4
heart rate
1
5.3
83.3
0
1.1
74.6
P wave terminal force measurement
0
133.5
74.5
resting heart rate
0
7.6
72.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroguidin
VGNC:3377
452802
Macaque
neuroguidin
714177
Mouse
MGI:1916216
68966
Rat
RGD:1310211
305887
Dog
neuroguidin
VGNC:43794
490612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroguidin
Macaque
neuroguidin
Mouse
Rat
Dog
neuroguidin
Publication Statistics
PubMed Score 70.46
PubMed score by year
PubTator Score 12.89
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title