Tbio NGDN Neuroguidin

Protein Summary

Description

Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NEJ9
• A8K760
• Q9Y400

Gene Name

• NGDN

Ensembl ID

• ENST00000397154
• ENSP00000380340
• ENSG00000129460
• ENST00000408901
• ENSP00000386134

Symbol

• C14orf120
• NGD
• LCP5
• CANu1
• lpd-2
• C14orf120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.94
kinase perturbation	0.93
transcription factor binding site profile	0.84
transcription factor perturbation	0.84
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.24   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.24   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0