Tbio NGDN Neuroguidin

Protein Summary

Description

Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs. Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NEJ9
• A8K760
• Q9Y400

Gene Name

• NGDN

Ensembl ID

• ENST00000397154
• ENSP00000380340
• ENSG00000129460
• ENST00000408901
• ENSP00000386134

Symbol

• C14orf120
• NGD
• LCP5
• CANu1
• lpd-2
• C14orf120

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.94
kinase perturbation	0.93
transcription factor binding site profile	0.84
transcription factor perturbation	0.84
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.46   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.46   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (281)

Explore Interacting Targets

1 – 10 of 281

• See Interactions on String-DB

NOL10

Tdark

Novelty:  0.27358884

p_int:  0.999988763

p_ni:  0.000011234

p_wrong:  3e-9

Score:  0.997

Data Source:  BioPlex,STRINGDB

RPS2

Tbio

Novelty:  0.00412313

p_int:  0.961164377

p_ni:  0.038835622

p_wrong:  1e-9

Score:  0.184

Data Source:  BioPlex,STRINGDB

ZNF512

Tbio

Family:  TF

Novelty:  0.08783629

p_int:  0.954318935

p_ni:  0.045662945

p_wrong:  0.000018121

Score:  0.209

Data Source:  BioPlex,STRINGDB

HIST1H1T

Tdark

Novelty:  0.01039464

p_int:  0.951029521

p_ni:  0.048969568

p_wrong:  9.11e-7

Data Source:  BioPlex

RPS14

Tbio

Novelty:  0.00576737

p_int:  0.929377893

p_ni:  0.070622096

p_wrong:  1.1e-8

Score:  0.485

Data Source:  BioPlex,STRINGDB

RPL18A

Tbio

Novelty:  0.04612948

p_int:  0.910315545

p_ni:  0.089684411

p_wrong:  4.4e-8

Score:  0.178

Data Source:  BioPlex,STRINGDB

GPATCH4

Tdark

Novelty:  1.13040547

p_int:  0.878924914

p_ni:  0.121075004

p_wrong:  8.2e-8

Score:  0.563

Data Source:  BioPlex,STRINGDB

RPS16

Tbio

Novelty:  0.00261983

p_int:  0.876697621

p_ni:  0.123302365

p_wrong:  1.5e-8

Score:  0.468

Data Source:  BioPlex,STRINGDB

FGF17

Tbio

Novelty:  0.01432991

p_int:  0.848167247

p_ni:  0.151832669

p_wrong:  8.5e-8

Data Source:  BioPlex

RNF151

Tdark

Novelty:  2.0077961

p_int:  0.815183609

p_ni:  0.184813793

p_wrong:  0.000002598

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (1)

Components (8)

Processes (2)

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10

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GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (11)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	2	1	61	5.3	83.4
heart rate	EFO_0004326	2	1	1	5.3	83.3
atrial fibrillation	EFO_0000275	2	2	0	1.1	74.6
P wave terminal force measurement	EFO_0008379	1	1	0	133.5	74.5
resting heart rate	EFO_0004351	1	2	0	7.6	72.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 11

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
electrocardiography	EFO_0004327	61	5.3	83.4
heart rate	EFO_0004326	1	5.3	83.3
atrial fibrillation	EFO_0000275	0	1.1	74.6
P wave terminal force measurement	EFO_0008379	0	133.5	74.5
resting heart rate	EFO_0004351	0	7.6	72.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Cell projection
Centromere
Chromosome
Coiled coil
Complete proteome
Cytoplasm
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
atrial fibrillation
electrocardiography
heart rate
P wave terminal force measurement
PR interval
pulse pressure measurement
QRS complex
QRS duration
QT interval
resting heart rate

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	neuroguidin	VGNC:3377	452802
Macaque	neuroguidin		714177
Mouse	neuroguidin, EIF4E binding protein	MGI:1916216	68966
Rat	neuroguidin	RGD:1310211	305887
Dog	neuroguidin	VGNC:43794	490612

Species	Name	OMA	EggNOG	Inparanoid
Chimp	neuroguidin
Macaque	neuroguidin
Mouse	neuroguidin, EIF4E binding protein
Rat	neuroguidin
Dog	neuroguidin

Publication Statistics

PubMed Score 70.46

PubMed score by year

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PubTator Score 12.89

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (3)

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10

0 of 0

PMID	Year	Title