Tbio MNS1 Meiosis-specific nuclear structural protein 1

Protein Summary

Description

May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q8NEH6
• Q8IYT6
• Q9NUP4

Gene Name

• MNS1

Ensembl ID

• ENST00000260453
• ENSP00000260453
• ENSG00000138587

Symbol

• SPATA40

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.75
transcription factor perturbation	0.68
cell line	0.66
tissue sample	0.65
gene perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Structural Protein / Meiosis-specific Nuclear Structural Protein 1

DTO Classes

Protein / Cellular Structure / Meiosis-specific Nuclear Structural Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.24   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.24   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0