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Tbio
ZSWIM2
E3 ubiquitin-protein ligase ZSWIM2

Protein Summary
Description
E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295131
  • ENSP00000295131
  • ENSG00000163012

Symbol
  • ZZZ2
  • MEX
  • ZZZ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.74
virus perturbation
0.59
protein domain
0.58
molecular function
0.49
cell line
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (33)
1 – 10 of 33
BCAM
Tbio
Novelty: 0.00384418
p_int: 0.999984337
p_ni: 0.000015658
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
TKTL2
Tbio
Family: Enzyme
Novelty: 0.08837116
p_int: 0.9999064
p_ni: 0.0000936
Score: 0.283
Data Source: BioPlex,STRINGDB
SEMG1
Tbio
Novelty: 0.01672941
p_int: 0.997415844
p_ni: 0.002584146
p_wrong: 1e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
LRFN4
Tbio
Novelty: 0.15441176
p_int: 0.989417402
p_ni: 0.010582597
p_wrong: 1e-9
Score: 0.195
Data Source: BioPlex,STRINGDB
RNASE7
Tbio
Family: Enzyme
Novelty: 0.02605465
p_int: 0.953484451
p_ni: 0.046391144
p_wrong: 0.000124404
Data Source: BioPlex
C2orf49
Tbio
Novelty: 0.00369413
Score: 0.836
Data Source: STRINGDB
TRIML1
Tdark
Family: Enzyme
Novelty: 1.63636364
Score: 0.693
Data Source: STRINGDB
EBNA1BP2
Tbio
Novelty: 0.02554881
Score: 0.66
Data Source: STRINGDB
PQLC2
Tdark
Novelty: 0.5
Score: 0.632
Data Source: STRINGDB
OXNAD1
Tdark
Family: Enzyme
Novelty: 2.1
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  204.89

PubMed score by year
PubTator Score  16.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer