You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SRFBP1
Serum response factor-binding protein 1

Protein Summary
Description
May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339397
  • ENSP00000341324
  • ENSG00000151304

Symbol
  • P49
  • Rlb1
  • BUD22
  • STRAP
  • p49/STRAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
ligand (protein) perturbation
0.83
virus perturbation
0.83
transcription factor binding site profile
0.8
hub protein
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.83   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.83   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
64.6
1
1
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
64.6
1
11.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serum response factor binding protein 1
VGNC:4182
741904
Macaque
serum response factor binding protein 1
699872
Mouse
MGI:1914472
67222
Rat
RGD:1359398
291469
Dog
serum response factor binding protein 1
VGNC:46800
608560
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serum response factor binding protein 1
Macaque
serum response factor binding protein 1
Mouse
Rat
Dog
serum response factor binding protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NEF9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
FBL
Tbio
Family: Enzyme
Novelty: 0.00080634
p_int: 0.999998091
p_ni: 0.000001909
Score: 0.185
Data Source: BioPlex,STRINGDB
RPS16
Tbio
Novelty: 0.00261983
p_int: 0.999980266
p_ni: 0.000016311
p_wrong: 0.000003423
Data Source: BioPlex
BYSL
Tbio
Novelty: 0.01919968
p_int: 0.999851293
p_ni: 0.000148707
Score: 0.727
Data Source: BioPlex,STRINGDB
FBXW5
Tbio
Novelty: 0.13100873
p_int: 0.997214495
p_ni: 0.000200414
p_wrong: 0.002585091
Score: 0.261
Data Source: BioPlex,STRINGDB
DDX10
Tbio
Family: Enzyme
Novelty: 0.03272208
p_int: 0.985839763
p_ni: 0.014160237
Score: 0.865
Data Source: BioPlex,STRINGDB
SRF
Tbio
Family: TF
Novelty: 0.00088839
Score: 0.813
Data Source: STRINGDB
LONP2
Tbio
Family: Enzyme
Novelty: 0.04499043
Score: 0.677
Data Source: STRINGDB
SLC2A4
Tbio
Family: Transporter
Novelty: 0.00033701
Score: 0.619
Data Source: STRINGDB
WDR36
Tbio
Novelty: 0.02010676
Score: 0.612
Data Source: STRINGDB
RSL1D1
Tbio
Novelty: 0.04525424
Score: 0.59
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.83

PubMed score by year
PubTator Score  11.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer