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Tdark
FBXL13
Dynein regulatory complex subunit 6

Protein Summary
Description
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXL13, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313221
  • ENSP00000321927
  • ENSG00000161040
  • ENST00000379305
  • ENSP00000368607
  • ENST00000436908
  • ENSP00000388608
  • ENST00000455112
  • ENSP00000391550
  • ENST00000456695
  • ENSP00000409716

Symbol
  • DRC6
  • FBL13
  • DRC6
  • Fbl13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor binding site profile
0.8
transcription factor
0.67
tissue sample
0.57
tissue
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.78   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.78   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (340)
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.980470843
p_ni:  0.019529157
Score:  0.436
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.973
Data Source:  STRINGDB
FBXW12
Tdark
Novelty:  0.27256341
Score:  0.973
Data Source:  STRINGDB
FBXL3
Tbio
Novelty:  0.05042679
Score:  0.972
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.969
Data Source:  STRINGDB
FBXL18
Tdark
Novelty:  0.33137957
Score:  0.959
Data Source:  STRINGDB
FBXW4
Tbio
Novelty:  0.06255177
Score:  0.948
Data Source:  STRINGDB
FBXL8
Tdark
Novelty:  0.84091737
Score:  0.942
Data Source:  STRINGDB
FBXL19
Tbio
Novelty:  0.07526966
Score:  0.941
Data Source:  STRINGDB
FBXW10
Tbio
Novelty:  0.11629778
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
7
4
1
96.6
2
2
1
1.1
57.8
circadian rhythm
1
1
0
1.1
28.1
1
1
0
10.7
24.5
mental or behavioural disorder
1
1
0
10.7
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
1
96.6
1
1.1
57.8
circadian rhythm
0
1.1
28.1
0
10.7
24.5
mental or behavioural disorder
0
10.7
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 13
VGNC:4354
463628
Macaque
F-box and leucine rich repeat protein 13
695089
Mouse
MGI:2443416
320118
Dog
F-box and leucine rich repeat protein 13
VGNC:51872
609997
Horse
F-box and leucine rich repeat protein 13
VGNC:52383
100058236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 13
Macaque
F-box and leucine rich repeat protein 13
Mouse
Dog
F-box and leucine rich repeat protein 13
Horse
F-box and leucine rich repeat protein 13
Publication Statistics
PubMed Score 2.78
PubMed score by year
PubTator Score 2.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title