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Tchem
CATSPER1
Cation channel sperm-associated protein 1

Protein Summary
Description
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312106
  • ENSP00000309052
  • ENSG00000175294

Symbol
  • SPGF7
  • CATSPER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
gene perturbation
0.76
cellular component
0.67
biological process
0.6
tissue
0.58


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.3   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.3   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated 1
VGNC:11279
451341
Mouse
MGI:2179947
225865
Dog
cation channel sperm associated 1
VGNC:38744
476016
Horse
cation channel sperm associated 1
VGNC:16080
100058005
Pig
cation channel sperm associated 1
100689223
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cation channel sperm associated 1
Mouse
Dog
cation channel sperm associated 1
Horse
cation channel sperm associated 1
Pig
cation channel sperm associated 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NEC5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Protein-Protein Interactions (83)
1 – 10 of 83
CATSPERG
Tdark
Novelty: 0.73161601
Score: 0.993
Data Source: Reactome,STRINGDB
CATSPERB
Tdark
Novelty: 0.69373919
Score: 0.981
Data Source: Reactome,STRINGDB
CATSPERD
Tdark
Novelty: 0.85066163
Score: 0.972
Data Source: Reactome,STRINGDB
CATSPER2
Tchem
Family: IC
Novelty: 0.03701031
Score: 0.955
Data Source: Reactome,STRINGDB
CATSPER4
Tchem
Family: IC
Novelty: 0.4554917
Score: 0.948
Data Source: Reactome,STRINGDB
HSPA2
Tbio
Novelty: 0.01696667
Score: 0.944
Data Source: STRINGDB
CATSPER3
Tchem
Family: IC
Novelty: 0.09919608
Score: 0.937
Data Source: Reactome,STRINGDB
HSPA1B
Tbio
Novelty: 0.01429214
Score: 0.916
Data Source: STRINGDB
CATSPERE
Tdark
Novelty: 0.95910237
Score: 0.883
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.04007679
Score: 0.829
Data Source: STRINGDB
Publication Statistics
PubMed Score  60.30

PubMed score by year
PubTator Score  62.03

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer