PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3
Protein Summary
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
- ENST00000262039
- ENSP00000262039
- ENSG00000078142
- VPS34
- VPS34
- Vps34
- hVps34
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.94 | ||
disease perturbation | 0.93 | ||
biological process | 0.88 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 408.92 (req: < 5)
Gene RIFs: 70 (req: <= 3)
Antibodies: 860 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 408.92 (req: >= 5)
Gene RIFs: 70 (req: > 3)
Antibodies: 860 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 41
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0