Tchem PIK3C3 Phosphatidylinositol 3-kinase catalytic subunit type 3

Protein Summary

Description

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).

Uniprot Accession IDs

• Q8NEB9
• Q15134
• PI3-kinase type 3

Gene Name

• PIK3C3

Ensembl ID

• ENST00000262039
• ENSP00000262039
• ENSG00000078142

Symbol

• VPS34
• VPS34
• Vps34
• hVps34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.94
disease perturbation	0.93
biological process	0.88
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Phosphatidylinositol 3-kinase Catalytic Subunit Type 3

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Pi3/pi4 Kinase Family / Phosphatidylinositol 3-kinase Catalytic Subunit Type 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.62   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 860   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.62   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 860   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (27)

Explore Active Ligands

1 – 10 of 27

torin 2

PIK3C3Tchem Kinase

pIC50 : 9.6

CHEMBL1615189

PIK3C3Tchem Kinase

pKi : 8.33

CHEMBL1738719

PIK3C3Tchem Kinase

pKi : 9.22

CHEMBL1914743

PIK3C3Tchem Kinase

pKi : 9.1

SAR260301

PIK3C3Tchem Kinase

pIC50 : 8.3

CHEMBL1914726

PIK3C3Tchem Kinase

pKi : 9.15

CHEMBL1914727

PIK3C3Tchem Kinase

pKi : 9.1

PQR620

PIK3C3Tchem Kinase

pKi : 7.97

CHEMBL4517404

PIK3C3Tchem Kinase

pIC50 : 8.7

CHEMBL4561242

PIK3C3Tchem Kinase

pIC50 : 8.8

Protein-Protein Interactions (318)

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1 – 10 of 318

• See Interactions on String-DB

NRBF2

Tbio

Novelty:  0.02432243

p_int:  0.999999998

p_ni:  2e-9

Score:  0.961

Data Source:  BioPlex,STRINGDB

RUBCNL

Tbio

Novelty:  0.20019585

p_int:  0.999999984

p_ni:  1.6e-8

Score:  0.396

Data Source:  BioPlex,STRINGDB

ATG14

Tbio

Novelty:  0.00914791

p_int:  0.99999991

p_ni:  5.5e-8

p_wrong:  3.6e-8

Score:  0.998

Data Source:  BioPlex,Reactome,STRINGDB

JADE2

Tbio

Family:  Epigenetic

Novelty:  0.19820849

p_int:  0.99997379

p_ni:  0.00002621

Score:  0.236

Data Source:  BioPlex,STRINGDB

SKAP1

Tbio

Family:  Enzyme

Novelty:  0.03753848

p_int:  0.999847047

p_ni:  0.000152953

Data Source:  BioPlex

LGALS7

Tbio

Novelty:  0.00753996

p_int:  0.983827907

p_ni:  0.016164656

p_wrong:  0.000007437

Score:  0.179

Data Source:  BioPlex,STRINGDB

PIK3R4

Tbio

Family:  Kinase

Novelty:  0.01412698

Score:  0.999

Data Source:  Reactome,STRINGDB

BECN1

Tbio

Novelty:  0.0003792

Score:  0.999

Data Source:  Reactome,STRINGDB

UVRAG

Tbio

Novelty:  0.01081083

Score:  0.998

Data Source:  Reactome,STRINGDB

ATG5

Tbio

Novelty:  0.00081472

Score:  0.993

Data Source:  STRINGDB

Nearest Tclin Targets (8)

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Upstream (6)

Downstream (2)

1 – 5 of 6

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  5

1: Kaposi sarcoma-associated herpesvirus infection

2: Inositol phosphate metabolism

3: Autophagy - animal

4: Metabolic pathways

5: Phosphatidylinositol signaling system

CALM1

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Kaposi sarcoma-associated herpesvirus infection

2: Apelin signaling pathway

3: Tuberculosis

4: Phosphatidylinositol signaling system

CALM2

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Kaposi sarcoma-associated herpesvirus infection

2: Apelin signaling pathway

3: Tuberculosis

4: Phosphatidylinositol signaling system

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  2

Common Pathways:  5

1: Kaposi sarcoma-associated herpesvirus infection

2: Inositol phosphate metabolism

3: Autophagy - animal

4: Metabolic pathways

5: Phosphatidylinositol signaling system

CALM3

Tclin

Family:  Other

KEGG Distance:  2

Common Pathways:  4

1: Kaposi sarcoma-associated herpesvirus infection

2: Apelin signaling pathway

3: Tuberculosis

4: Phosphatidylinositol signaling system

Pathways (107)

Reactome (30)

KEGG (9)

PathwayCommons (12)

WikiPathways (56)

Autophagy (R-HSA-9612973)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	FLT3 Signaling	264 targets	R-HSA-9607240
Reactome	IGF1R signaling cascade	53 targets	R-HSA-2428924

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
FLT3 Signaling	264 targets	R-HSA-9607240
IGF1R signaling cascade	53 targets	R-HSA-2428924

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (39)

Functions (4)

Components (14)

Processes (21)

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1 – 4 of 4

GO Term	Evidence	Assigned by
kinase activity	Inferred from Direct Assay (IDA)	MGI
1-phosphatidylinositol-3-kinase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein kinase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		49.5
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		8.6

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		49.5
comparative body size at age 10, self-reported	EFO_0009819	1		8.6

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UniProt Keyword Find Similar Targets

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3D-structure
ATP-binding
Autophagy
Cell cycle
Cell division
Complete proteome
Cytoplasmic vesicle
Endosome
Kinase
Manganese

GWAS Trait Find Similar Targets

No Header	No Header
body height
comparative body size at age 10, self-reported

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol 3-kinase catalytic subunit type 3	VGNC:7328	455385
Macaque	phosphatidylinositol 3-kinase catalytic subunit type 3		693918
Mouse	phosphatidylinositol 3-kinase catalytic subunit type 3	MGI:2445019	225326
Rat	phosphatidylinositol 3-kinase, catalytic subunit type 3	RGD:620899	65052
Dog	phosphatidylinositol 3-kinase catalytic subunit type 3	VGNC:44554	490477

Species	Name	OMA	EggNOG	Inparanoid
Chimp	phosphatidylinositol 3-kinase catalytic subunit type 3
Macaque	phosphatidylinositol 3-kinase catalytic subunit type 3
Mouse	phosphatidylinositol 3-kinase catalytic subunit type 3
Rat	phosphatidylinositol 3-kinase, catalytic subunit type 3
Dog	phosphatidylinositol 3-kinase catalytic subunit type 3

Publication Statistics

PubMed Score 365.62

PubMed score by year

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PubTator Score 162.07

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Patents

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Related Publications

Text Mined References (104)

GeneRif Annotations (54)

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PMID	Year	Title