Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).

Uniprot Accession IDs

Gene Name

PIK3C3

Ensembl ID

ENST00000262039
ENSP00000262039
ENSG00000078142

Symbol

VPS34
VPS34
Vps34
hVps34

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99

molecular function	0.94

disease perturbation	0.93

biological process	0.88

kinase perturbation	0.88

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.83 (req: < 5)

View Publications

Gene RIFs: 54 (req: <= 3)

View Gene RIFs

Antibodies: 860 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.83 (req: >= 5)

Gene RIFs: 54 (req: > 3)

Antibodies: 860 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (13)

1 – 10 of 13

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		29.6

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		29.6

Beta Count

Odds Ratio

Protein Data Bank (11)

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (107)

Reactome (30)

KEGG (9)

PathwayCommons (12)

WikiPathways (56)

Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 30

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973

Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	FLT3 Signaling	264 targets	R-HSA-9607240

Reactome	IGF1R signaling cascade	53 targets	R-HSA-2428924

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973

Cellular responses to external stimuli	487 targets	R-HSA-8953897

Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

FLT3 Signaling	264 targets	R-HSA-9607240

IGF1R signaling cascade	53 targets	R-HSA-2428924

Gene Ontology Terms (39)

Functions (4)

Components (14)

Processes (21)

Items per page:

1 – 4 of 4

GO Term	Evidence	Assigned by
kinase activity	Inferred from Direct Assay (IDA)	MGI

1-phosphatidylinositol-3-kinase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

protein kinase activity	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (318)

1 – 10 of 318

See Interactions on String-DB

NRBF2

Tbio

Novelty: 0.02432243

p_int: 0.999999998

p_ni: 2e-9

Score: 0.961

Data Source: BioPlex,STRINGDB

RUBCNL

Tbio

Novelty: 0.20019585

p_int: 0.999999984

p_ni: 1.6e-8

Score: 0.396

Data Source: BioPlex,STRINGDB

ATG14

Tbio

Novelty: 0.00914791

p_int: 0.99999991

p_ni: 5.5e-8

p_wrong: 3.6e-8

Score: 0.998

Data Source: BioPlex,Reactome,STRINGDB

JADE2

Tbio

Family: Epigenetic

Novelty: 0.19820849

p_int: 0.99997379

p_ni: 0.00002621

Score: 0.236

Data Source: BioPlex,STRINGDB

SKAP1

Tbio

Family: Enzyme

Novelty: 0.03753848

p_int: 0.999847047

p_ni: 0.000152953

Data Source: BioPlex

LGALS7

Tbio

Novelty: 0.00753996

p_int: 0.983827907

p_ni: 0.016164656

p_wrong: 0.000007437

Score: 0.179

Data Source: BioPlex,STRINGDB

PIK3R4

Tbio

Family: Kinase

Novelty: 0.01412698

Score: 0.999

Data Source: Reactome,STRINGDB

BECN1

Tbio

Novelty: 0.0003792

Score: 0.999

Data Source: Reactome,STRINGDB

UVRAG

Tbio

Novelty: 0.01081083

Score: 0.998

Data Source: Reactome,STRINGDB

ATG5

Tbio

Novelty: 0.00081472

Score: 0.993

Data Source: STRINGDB

Publication Statistics

PubMed Score 351.83

PubMed score by year

PubTator Score 162.07

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Find similar targets by:

UniProt Keyword


3D-structure

ATP-binding

Autophagy

Cell cycle

Cell division

Complete proteome

Cytoplasmic vesicle

Endosome

Kinase

Manganese

GWAS Trait


body height

MGI Phenotype


behavior/neurological phenotype

cardiovascular system phenotype

cellular phenotype

embryo phenotype

growth/size/body region phenotype

hematopoietic system phenotype

homeostasis/metabolism phenotype

immune system phenotype

liver/biliary system phenotype

mortality/aging