PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3
Protein Summary
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
- ENST00000262039
- ENSP00000262039
- ENSG00000078142
- VPS34
- VPS34
- Vps34
- hVps34
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.94 | ||
disease perturbation | 0.93 | ||
biological process | 0.88 | ||
kinase perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 408.92 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 860 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 408.92 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 860 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 41
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (41)
Protein-Protein Interactions (318)
NRBF2
Novelty: 0.02432243
p_int: 0.999999998
p_ni: 2e-9
Score: 0.961
Data Source: BioPlex,STRINGDB
RUBCNL
Novelty: 0.20019585
p_int: 0.999999984
p_ni: 1.6e-8
Score: 0.396
Data Source: BioPlex,STRINGDB
ATG14
Novelty: 0.00914791
p_int: 0.99999991
p_ni: 5.5e-8
p_wrong: 3.6e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
JADE2
Family: Epigenetic
Novelty: 0.19820849
p_int: 0.99997379
p_ni: 0.00002621
Score: 0.236
Data Source: BioPlex,STRINGDB
SKAP1
Family: Enzyme
Novelty: 0.03753848
p_int: 0.999847047
p_ni: 0.000152953
Data Source: BioPlex
LGALS7
Novelty: 0.00753996
p_int: 0.983827907
p_ni: 0.016164656
p_wrong: 0.000007437
Score: 0.179
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (8)
Upstream (6)
Downstream (2)
1 – 5 of 6
Pathways (107)
Reactome (30)
KEGG (9)
PathwayCommons (12)
WikiPathways (56)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | FLT3 Signaling | ||||
Reactome | IGF1R signaling cascade | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Cellular responses to external stimuli | ||||
Cytokine Signaling in Immune system | ||||
FLT3 Signaling | ||||
IGF1R signaling cascade | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (4)
Components (14)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 52.9 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 9.6 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 52.9 | |||||
comparative body size at age 10, self-reported | 1 | 9.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | phosphatidylinositol 3-kinase catalytic subunit type 3 | VGNC:7328 | 455385 | |||||
Macaque | phosphatidylinositol 3-kinase catalytic subunit type 3 | 693918 | ||||||
Mouse | MGI:2445019 | 225326 | ||||||
Rat | RGD:620899 | 65052 | ||||||
Dog | phosphatidylinositol 3-kinase catalytic subunit type 3 | VGNC:44554 | 490477 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | phosphatidylinositol 3-kinase catalytic subunit type 3 | |||||
Macaque | phosphatidylinositol 3-kinase catalytic subunit type 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | phosphatidylinositol 3-kinase catalytic subunit type 3 | |||||
Publication Statistics
PubMed Score 408.92
PubMed score by year
PubTator Score 162.07
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (104)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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