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Tchem
PIK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

Protein Summary
Description
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262039
  • ENSP00000262039
  • ENSG00000078142

Symbol
  • VPS34
  • VPS34
  • Vps34
  • hVps34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.94
disease perturbation
0.93
biological process
0.88
kinase perturbation
0.88


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.62   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 860   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 365.62   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 860   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
49.5
comparative body size at age 10, self-reported
1
1
1
8.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
49.5
comparative body size at age 10, self-reported
1
8.6
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 3-kinase catalytic subunit type 3
VGNC:7328
455385
Macaque
phosphatidylinositol 3-kinase catalytic subunit type 3
693918
Mouse
MGI:2445019
225326
Rat
RGD:620899
65052
Dog
phosphatidylinositol 3-kinase catalytic subunit type 3
VGNC:44554
490477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphatidylinositol 3-kinase catalytic subunit type 3
Macaque
phosphatidylinositol 3-kinase catalytic subunit type 3
Mouse
Rat
Dog
phosphatidylinositol 3-kinase catalytic subunit type 3
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NEB9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (107)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IGF1R signaling cascade
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Cytokine Signaling in Immune system
FLT3 Signaling
IGF1R signaling cascade
Gene Ontology Terms (39)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (318)
1 – 10 of 318
NRBF2
Tbio
Novelty:  0.02432243
p_int:  0.999999998
p_ni:  2e-9
Score:  0.961
Data Source:  BioPlex,STRINGDB
RUBCNL
Tbio
Novelty:  0.20019585
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.396
Data Source:  BioPlex,STRINGDB
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.99999991
p_ni:  5.5e-8
p_wrong:  3.6e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.99997379
p_ni:  0.00002621
Score:  0.236
Data Source:  BioPlex,STRINGDB
SKAP1
Tbio
Family:  Enzyme
Novelty:  0.03753848
p_int:  0.999847047
p_ni:  0.000152953
Data Source:  BioPlex
LGALS7
Tbio
Novelty:  0.00753996
p_int:  0.983827907
p_ni:  0.016164656
p_wrong:  0.000007437
Score:  0.179
Data Source:  BioPlex,STRINGDB
PIK3R4
Tbio
Family:  Kinase
Novelty:  0.01412698
Score:  0.999
Data Source:  Reactome,STRINGDB
BECN1
Tbio
Novelty:  0.0003792
Score:  0.999
Data Source:  Reactome,STRINGDB
UVRAG
Tbio
Novelty:  0.01081083
Score:  0.998
Data Source:  Reactome,STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.993
Data Source:  STRINGDB
Publication Statistics
PubMed Score  365.62

PubMed score by year
PubTator Score  162.07

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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