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Tbio
PLPP5
Phospholipid phosphatase 5

Protein Summary
Description
Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419686
  • ENSP00000414522
  • ENSG00000147535
  • ENST00000422581
  • ENSP00000390622
  • ENST00000424479
  • ENSP00000392553
  • ENST00000529359
  • ENSP00000434916

Symbol
  • DPPL1
  • HTPAP
  • PPAPDC1B
  • DPPL1
  • HTPAP
  • PPAPDC1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.62   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.62   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Role of phospholipids in phagocytosis
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
Role of phospholipids in phagocytosis
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (75)
1 – 10 of 75
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.92
Data Source: STRINGDB
DGAT2
Tchem
Family: Enzyme
Novelty: 0.00488581
Score: 0.915
Data Source: STRINGDB
MOGAT2
Tchem
Family: Enzyme
Novelty: 0.06314447
Score: 0.915
Data Source: STRINGDB
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.915
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.914
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.914
Data Source: STRINGDB
CDS2
Tbio
Family: Enzyme
Novelty: 0.13210626
Score: 0.912
Data Source: STRINGDB
CDS1
Tbio
Family: Enzyme
Novelty: 0.08094799
Score: 0.912
Data Source: STRINGDB
CEPT1
Tbio
Family: Enzyme
Novelty: 0.01816476
Score: 0.907
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.02875977
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.62

PubMed score by year
PubTator Score  6.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer