You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GLIS3
Zinc finger protein GLIS3

Protein Summary
Description
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324333
  • ENSP00000325494
  • ENSG00000107249
  • ENST00000381971
  • ENSP00000371398

Symbol
  • ZNF515
  • NDH
  • ZNF515
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.93
molecular function
0.88
PubMedID
0.65
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 584.57   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 584.57   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
99
sex hormone-binding globulin measurement
6
4
10
98.7
intraocular pressure measurement
5
4
5
8.5
94
neuroticism measurement
4
3
2
5.9
86
forced expiratory volume
2
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
99
sex hormone-binding globulin measurement
10
98.7
intraocular pressure measurement
5
8.5
94
neuroticism measurement
2
5.9
86
forced expiratory volume
2
83.6
Protein-Protein Interactions (90)
1 – 10 of 90
GPR152
Tbio
Family: GPCR
Novelty: 0.02032351
Score: 0.793
Data Source: STRINGDB
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
Score: 0.772
Data Source: STRINGDB
DECR1
Tbio
Family: Enzyme
Novelty: 0.02699187
Score: 0.729
Data Source: STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
Score: 0.724
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.714
Data Source: STRINGDB
TSC1
Tbio
Novelty: 0.00406614
Score: 0.691
Data Source: STRINGDB
RFX6
Tbio
Family: TF
Novelty: 0.02967745
Score: 0.673
Data Source: STRINGDB
PKD1L1
Tbio
Family: IC
Novelty: 0.08309821
Score: 0.667
Data Source: STRINGDB
C2CD4B
Tbio
Novelty: 0.12755154
Score: 0.656
Data Source: STRINGDB
SLC1A1
Tchem
Family: Transporter
Novelty: 0.00218479
Score: 0.649
Data Source: STRINGDB
Publication Statistics
PubMed Score  584.57

PubMed score by year
PubTator Score  63.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: