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Tbio
GLIS3
Zinc finger protein GLIS3

Protein Summary
Description
Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity). This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324333
  • ENSP00000325494
  • ENSG00000107249
  • ENST00000381971
  • ENSP00000371398

Symbol
  • ZNF515
  • NDH
  • ZNF515
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.93
molecular function
0.88
PubMedID
0.65
transcription factor binding site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 612.23   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 612.23   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
GPR152
Tbio
Family:  GPCR
Novelty:  0.02032351
Score:  0.793
Data Source:  STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
Score:  0.772
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.729
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.724
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.714
Data Source:  STRINGDB
TSC1
Tbio
Novelty:  0.00406614
Score:  0.691
Data Source:  STRINGDB
RFX6
Tbio
Family:  TF
Novelty:  0.02967745
Score:  0.673
Data Source:  STRINGDB
PKD1L1
Tbio
Family:  IC
Novelty:  0.08309821
Score:  0.667
Data Source:  STRINGDB
C2CD4B
Tbio
Novelty:  0.12755154
Score:  0.656
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.649
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (47)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
5
4
1.1
94.9
intraocular pressure measurement
5
4
5
8.5
94.6
glucose measurement
4
3
4
92.7
sex hormone-binding globulin measurement
6
4
10
92.6
forced expiratory volume
2
2
2
84
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
94.9
intraocular pressure measurement
5
8.5
94.6
glucose measurement
4
92.7
sex hormone-binding globulin measurement
10
92.6
forced expiratory volume
2
84
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GLIS family zinc finger 3
VGNC:13883
464973
Mouse
MGI:2444289
226075
Rat
Dog
GLIS family zinc finger 3
VGNC:41263
484179
Horse
GLIS family zinc finger 3
VGNC:18379
100051202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GLIS family zinc finger 3
Mouse
Rat
Dog
GLIS family zinc finger 3
Horse
GLIS family zinc finger 3
Publication Statistics
PubMed Score 612.23
PubMed score by year
PubTator Score 63.88
PubTator score by year
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Related Publications
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PMID
Year
Title