You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MCU
Calcium uniporter protein, mitochondrial

Protein Classes
Protein Summary
Description
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria (PubMed:21685888, PubMed:21685886, PubMed:23101630, PubMed:22904319, PubMed:23178883, PubMed:22829870, PubMed:22822213, PubMed:24332854, PubMed:23755363, PubMed:26341627). Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (PubMed:23755363). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (PubMed:24560927, PubMed:26903221). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes (PubMed:22822213). While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357157
  • ENSP00000349680
  • ENSG00000156026
  • ENST00000373053
  • ENSP00000362144
  • ENST00000536019
  • ENSP00000440913

Symbol
  • C10orf42
  • CCDC109A
  • HsMCU
  • C10orf42
  • CCDC109A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
cellular component
0.75
kinase perturbation
0.71
biological process
0.69
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 950.93   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 950.93   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
1
1
80.9
red blood cell distribution width
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
80.9
red blood cell distribution width
1
17.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uniporter
VGNC:4745
466291
Macaque
mitochondrial calcium uniporter
708334
Mouse
MGI:3026965
215999
Rat
RGD:1589771
294560
Dog
mitochondrial calcium uniporter
VGNC:43096
489042
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial calcium uniporter
Macaque
mitochondrial calcium uniporter
Mouse
Rat
Dog
mitochondrial calcium uniporter
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Gene Ontology Terms (16)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (92)
1 – 10 of 92
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
p_int: 0.999997105
p_ni: 0.000002895
Score: 0.271
Data Source: BioPlex,STRINGDB
TOR1AIP2
Tbio
Novelty: 0.08912351
p_int: 0.996467753
p_ni: 0.003532247
Data Source: BioPlex
EDEM2
Tbio
Family: Enzyme
Novelty: 0.1180208
p_int: 0.959526153
p_ni: 0.040473847
Data Source: BioPlex
GNAI2
Tbio
Novelty: 0.03014729
p_int: 0.953051512
p_ni: 0.046948488
Score: 0.216
Data Source: BioPlex,STRINGDB
SLC5A8
Tchem
Family: Transporter
Novelty: 0.00892277
p_int: 0.925602397
p_ni: 0.074397603
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.920936228
p_ni: 0.079063771
p_wrong: 1e-9
Data Source: BioPlex
APLNR
Tchem
Family: GPCR
Novelty: 0.00224203
p_int: 0.911459448
p_ni: 0.088540552
Data Source: BioPlex
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
p_int: 0.910977279
p_ni: 0.089022721
Data Source: BioPlex
IRGC
Tbio
Family: Enzyme
Novelty: 0.10743948
p_int: 0.903577259
p_ni: 0.096422741
Score: 0.179
Data Source: BioPlex,STRINGDB
HSD17B1
Tchem
Family: Enzyme
Novelty: 0.00313425
p_int: 0.874080362
p_ni: 0.125919638
Data Source: BioPlex
Publication Statistics
PubMed Score  950.93

PubMed score by year
PubTator Score  164.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: