Tbio ABCF1 ATP-binding cassette sub-family F member 1

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family F Member 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Atp-binding Cassette Sub-family F Member 1

Protein / Hydrolase / Atp-binding Cassette Sub-family F Member 1

Protein Summary

Description

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NE71
• A2BF75
• O14897
• Q69YP6

Gene Name

• ABCF1

Ensembl ID

• ENST00000326195
• ENSP00000313603
• ENSG00000204574
• ENST00000376545
• ENSP00000365728
• ENST00000383587
• ENSP00000373081
• ENSG00000206490
• ENST00000383588
• ENSP00000373082
• ENST00000412443
• ENSP00000404726
• ENSG00000236342
• ENST00000419893
• ENSP00000389065
• ENSG00000232169
• ENST00000420257
• ENSP00000391102
• ENSG00000225989
• ENST00000421042
• ENSP00000393143
• ENSG00000231129
• ENST00000423247
• ENSP00000411327
• ENST00000426219
• ENSP00000414373
• ENST00000448939
• ENSP00000403526
• ENST00000452530
• ENSP00000389472
• ENSG00000236149
• ENST00000457078
• ENSP00000412553
• ENST00000457111
• ENSP00000413319

Symbol

• ABC50
• ABC27
• ABC50

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	1
interacting protein	0.99
molecular function	0.96
kinase perturbation	0.93

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.21   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.21   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (2)

Reactome (2)

ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
ABC-family proteins mediated transport	104 targets	R-HSA-382556
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (18)

Functions (6)

Components (7)

Processes (5)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
ribosome binding	Inferred from Direct Assay (IDA)	UniProtKB
translation activator activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
translation factor activity, RNA binding	Traceable Author Statement (TAS)	ProtInc
ATPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (101)

Explore Interacting Targets

1 – 10 of 101

• See Interactions on String-DB

CDC5L

Tbio

Family: TF

Novelty: 0.00617757

Score: 0.983

Data Source: STRINGDB

ABCE1

Tbio

Family: Transporter

Novelty: 0.00508003

Score: 0.956

Data Source: STRINGDB

EIF2S2

Tbio

Novelty: 0.017562

Score: 0.951

Data Source: Reactome,STRINGDB

RPS28

Tbio

Novelty: 0.04810298

Score: 0.948

Data Source: STRINGDB

RPL11

Tbio

Novelty: 0.00566877

Score: 0.947

Data Source: STRINGDB

RPL10A

Tbio

Novelty: 0.02288439

Score: 0.943

Data Source: STRINGDB

EIF2S1

Tbio

Novelty: 0.00157698

Score: 0.932

Data Source: Reactome,STRINGDB

RPS23

Tbio

Novelty: 0.0085808

Score: 0.925

Data Source: STRINGDB

DHX9

Tbio

Family: Enzyme

Novelty: 0.00143599

Score: 0.924

Data Source: STRINGDB

RPL8

Tbio

Novelty: 0.03315002

Score: 0.915

Data Source: STRINGDB

Publication Statistics

PubMed Score  19.21

PubMed score by year

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PubTator Score  19.01

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ

1-70

QQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQS

70-140

EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKE

140-210

KEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAA

210-280

ENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIA

280-350

NRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR

350-420

ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWL

420-490

NNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKE

490-560

LKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGV

560-630

TFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQ

630-700

LRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPT

700-770

NNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV

770-840

SRPRE

840-845

MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE

Find similar targets by:

Uniprot Keyword

3D-structure
Activator
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism