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Tbio
ABCF1
ATP-binding cassette sub-family F member 1

Protein Summary
Description
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326195
  • ENSP00000313603
  • ENSG00000204574
  • ENST00000376545
  • ENSP00000365728
  • ENST00000383587
  • ENSP00000373081
  • ENSG00000206490
  • ENST00000383588
  • ENSP00000373082
  • ENST00000412443
  • ENSP00000404726
  • ENSG00000236342
  • ENST00000419893
  • ENSP00000389065
  • ENSG00000232169
  • ENST00000420257
  • ENSP00000391102
  • ENSG00000225989
  • ENST00000421042
  • ENSP00000393143
  • ENSG00000231129
  • ENST00000423247
  • ENSP00000411327
  • ENST00000426219
  • ENSP00000414373
  • ENST00000448939
  • ENSP00000403526
  • ENST00000452530
  • ENSP00000389472
  • ENSG00000236149
  • ENST00000457078
  • ENSP00000412553
  • ENST00000457111
  • ENSP00000413319

Symbol
  • ABC50
  • ABC27
  • ABC50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
drug perturbation
1
interacting protein
0.99
molecular function
0.96
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.983
Data Source:  STRINGDB
ABCE1
Tbio
Family:  Transporter
Novelty:  0.00529126
Score:  0.956
Data Source:  STRINGDB
EIF2S2
Tbio
Novelty:  0.0146918
Score:  0.951
Data Source:  Reactome,STRINGDB
RPS28
Tbio
Novelty:  0.03303065
Score:  0.948
Data Source:  STRINGDB
RPL11
Tbio
Novelty:  0.00448962
Score:  0.947
Data Source:  STRINGDB
RPL10A
Tbio
Novelty:  0.01747453
Score:  0.943
Data Source:  STRINGDB
EIF2S1
Tbio
Novelty:  0.00076124
Score:  0.932
Data Source:  Reactome,STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.925
Data Source:  STRINGDB
DHX9
Tbio
Family:  Enzyme
Novelty:  0.00130907
Score:  0.924
Data Source:  STRINGDB
RPL8
Tbio
Novelty:  0.01064076
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (138)
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.2
83.1
2
3
0
1.2
83.1
2
3
0
1.2
83.1
2
3
0
1.2
83.1
2
3
0
1.2
83.1
Items per page:
1 – 5 of 138
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.1
0
1.2
83.1
0
1.2
83.1
0
1.2
83.1
0
1.2
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily F member 1
VGNC:11027
462543
Macaque
ATP binding cassette subfamily F member 1
711864
Mouse
MGI:1351658
224742
Rat
RGD:620286
85493
Dog
ATP binding cassette subfamily F member 1
VGNC:37450
474826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily F member 1
Macaque
ATP binding cassette subfamily F member 1
Mouse
Rat
Dog
ATP binding cassette subfamily F member 1
Publication Statistics
PubMed Score 27.01
PubMed score by year
PubTator Score 19.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title