Tbio ABCF1 ATP-binding cassette sub-family F member 1

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family F Member 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Atp-binding Cassette Sub-family F Member 1

Protein / Hydrolase / Atp-binding Cassette Sub-family F Member 1

DTO Classes

Protein / Enzyme / Hydrolase / Atp-binding Cassette Sub-family F Member 1

Protein Summary

Description

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NE71
• A2BF75
• O14897
• Q69YP6

Gene Name

• ABCF1

Ensembl ID

• ENST00000326195
• ENSP00000313603
• ENSG00000204574
• ENST00000376545
• ENSP00000365728
• ENST00000383587
• ENSP00000373081
• ENSG00000206490
• ENST00000383588
• ENSP00000373082
• ENST00000412443
• ENSP00000404726
• ENSG00000236342
• ENST00000419893
• ENSP00000389065
• ENSG00000232169
• ENST00000420257
• ENSP00000391102
• ENSG00000225989
• ENST00000421042
• ENSP00000393143
• ENSG00000231129
• ENST00000423247
• ENSP00000411327
• ENST00000426219
• ENSP00000414373
• ENST00000448939
• ENSP00000403526
• ENST00000452530
• ENSP00000389472
• ENSG00000236149
• ENST00000457078
• ENSP00000412553
• ENST00000457111
• ENSP00000413319

Symbol

• ABC50
• ABC27
• ABC50

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	1
interacting protein	0.99
molecular function	0.96
kinase perturbation	0.93

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.2   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.2   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (16)

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum IgM measurement	EFO_0004993	ENSG00000232169	1	1	1		67.5
serum IgM measurement	EFO_0004993	ENSG00000206490	1	1	1		67.5
serum IgM measurement	EFO_0004993	ENSG00000236149	1	1	1		67.5
serum IgM measurement	EFO_0004993	ENSG00000225989	1	1	1		67.5
serum IgM measurement	EFO_0004993	ENSG00000231129	1	1	1		67.5

Items per page:

5

1 – 5 of 16

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
serum IgM measurement	EFO_0004993	1		67.5
serum IgM measurement	EFO_0004993	1		67.5
serum IgM measurement	EFO_0004993	1		67.5
serum IgM measurement	EFO_0004993	1		67.5
serum IgM measurement	EFO_0004993	1		67.5

Reset Zoom  Beta Count   Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ATP binding cassette subfamily F member 1	VGNC:11027	462543
Macaque	ATP binding cassette subfamily F member 1		711864
Mouse	ATP-binding cassette, sub-family F (GCN20), member 1	MGI:1351658	224742
Rat	ATP binding cassette subfamily F member 1	RGD:620286	85493
Dog	ATP binding cassette subfamily F member 1	VGNC:37450	474826

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ATP binding cassette subfamily F member 1
Macaque	ATP binding cassette subfamily F member 1
Mouse	ATP-binding cassette, sub-family F (GCN20), member 1
Rat	ATP binding cassette subfamily F member 1
Dog	ATP binding cassette subfamily F member 1

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8NE71-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (2)

Reactome (2)

ABC-family proteins mediated transport (R-HSA-382556)

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Find Similar Targets

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1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ABC-family proteins mediated transport	104 targets	R-HSA-382556
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
ABC-family proteins mediated transport	104 targets	R-HSA-382556
Transport of small molecules	725 targets	R-HSA-382551

Gene Ontology Terms (18)

Functions (6)

Components (7)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	UniProtKB
ribosome binding	Inferred from Direct Assay (IDA)	UniProtKB
translation activator activity	Inferred from Direct Assay (IDA)	UniProtKB
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
translation factor activity, RNA binding	Traceable Author Statement (TAS)	ProtInc
ATPase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (101)

Explore Interacting Targets

1 – 10 of 101

• See Interactions on String-DB

CDC5L

Tbio

Family: TF

Novelty: 0.00663599

Score: 0.983

Data Source: STRINGDB

ABCE1

Tbio

Family: Transporter

Novelty: 0.00529126

Score: 0.956

Data Source: STRINGDB

EIF2S2

Tbio

Novelty: 0.0146918

Score: 0.951

Data Source: Reactome,STRINGDB

RPS28

Tbio

Novelty: 0.03303065

Score: 0.948

Data Source: STRINGDB

RPL11

Tbio

Novelty: 0.00448962

Score: 0.947

Data Source: STRINGDB

RPL10A

Tbio

Novelty: 0.01747453

Score: 0.943

Data Source: STRINGDB

EIF2S1

Tbio

Novelty: 0.00076124

Score: 0.932

Data Source: Reactome,STRINGDB

RPS23

Tbio

Novelty: 0.01846154

Score: 0.925

Data Source: STRINGDB

DHX9

Tbio

Family: Enzyme

Novelty: 0.00130907

Score: 0.924

Data Source: STRINGDB

RPL8

Tbio

Novelty: 0.01064076

Score: 0.915

Data Source: STRINGDB

Publication Statistics

PubMed Score  26.20

PubMed score by year

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PubTator Score  19.01

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Activator
Alternative splicing
ATP-binding
Complete proteome
Cytoplasm
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

influenza A (H1N1)
intelligence
schizophrenia
serum IgM measurement

MGI Phenotype Find Similar Targets

mortality/aging