ABCF1
ATP-binding cassette sub-family F member 1
Protein Summary
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
- ENST00000326195
- ENSP00000313603
- ENSG00000204574
- ENST00000376545
- ENSP00000365728
- ENST00000383587
- ENSP00000373081
- ENSG00000206490
- ENST00000383588
- ENSP00000373082
- ENST00000412443
- ENSP00000404726
- ENSG00000236342
- ENST00000419893
- ENSP00000389065
- ENSG00000232169
- ENST00000420257
- ENSP00000391102
- ENSG00000225989
- ENST00000421042
- ENSP00000393143
- ENSG00000231129
- ENST00000423247
- ENSP00000411327
- ENST00000426219
- ENSP00000414373
- ENST00000448939
- ENSP00000403526
- ENST00000452530
- ENSP00000389472
- ENSG00000236149
- ENST00000457078
- ENSP00000412553
- ENST00000457111
- ENSP00000413319
- ABC50
- ABC27
- ABC50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
drug perturbation | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.96 | ||
kinase perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.01 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 269 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.01 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 269 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ABC-family proteins mediated transport | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (138)
Items per page:
1 – 5 of 138
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
2 | 3 | 0 | 1.2 | 83.1 | ||||||
2 | 3 | 0 | 1.2 | 83.1 | ||||||
2 | 3 | 0 | 1.2 | 83.1 | ||||||
2 | 3 | 0 | 1.2 | 83.1 | ||||||
2 | 3 | 0 | 1.2 | 83.1 | ||||||
Items per page:
1 – 5 of 138
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 83.1 | |||||
0 | 1.2 | 83.1 | |||||
0 | 1.2 | 83.1 | |||||
0 | 1.2 | 83.1 | |||||
0 | 1.2 | 83.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily F member 1 | VGNC:11027 | 462543 | |||||
Macaque | ATP binding cassette subfamily F member 1 | 711864 | ||||||
Mouse | MGI:1351658 | 224742 | ||||||
Rat | RGD:620286 | 85493 | ||||||
Dog | ATP binding cassette subfamily F member 1 | VGNC:37450 | 474826 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily F member 1 | |||||
Macaque | ATP binding cassette subfamily F member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP binding cassette subfamily F member 1 | |||||
Publication Statistics
PubMed Score 27.01
PubMed score by year
PubTator Score 19.01
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (14)
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0 of 0
PMID | Year | Title |
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