ABCF1
ATP-binding cassette sub-family F member 1
Protein Classes
Protein Summary
Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]
- ENST00000326195
- ENSP00000313603
- ENSG00000204574
- ENST00000376545
- ENSP00000365728
- ENST00000383587
- ENSP00000373081
- ENSG00000206490
- ENST00000383588
- ENSP00000373082
- ENST00000412443
- ENSP00000404726
- ENSG00000236342
- ENST00000419893
- ENSP00000389065
- ENSG00000232169
- ENST00000420257
- ENSP00000391102
- ENSG00000225989
- ENST00000421042
- ENSP00000393143
- ENSG00000231129
- ENST00000423247
- ENSP00000411327
- ENST00000426219
- ENSP00000414373
- ENST00000448939
- ENSP00000403526
- ENST00000452530
- ENSP00000389472
- ENSG00000236149
- ENST00000457078
- ENSP00000412553
- ENST00000457111
- ENSP00000413319
- ABC50
- ABC27
- ABC50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
drug perturbation | 1 | ||
interacting protein | 0.99 | ||
molecular function | 0.96 | ||
kinase perturbation | 0.93 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.2 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 269 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.2 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 269 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
serum IgM measurement | 1 | 1 | 1 | 67.5 | ||||||
serum IgM measurement | 1 | 1 | 1 | 67.5 | ||||||
serum IgM measurement | 1 | 1 | 1 | 67.5 | ||||||
serum IgM measurement | 1 | 1 | 1 | 67.5 | ||||||
serum IgM measurement | 1 | 1 | 1 | 67.5 | ||||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
serum IgM measurement | 1 | 67.5 | |||||
serum IgM measurement | 1 | 67.5 | |||||
serum IgM measurement | 1 | 67.5 | |||||
serum IgM measurement | 1 | 67.5 | |||||
serum IgM measurement | 1 | 67.5 | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 2 of 2
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ABC-family proteins mediated transport | ||||
Transport of small molecules | ||||
Gene Ontology Terms (18)
Functions (6)
Components (7)
Processes (5)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (101)
1 – 10 of 101
CDC5L
Family: TF
Novelty: 0.00663599
Score: 0.983
Data Source: STRINGDB
ABCE1
Family: Transporter
Novelty: 0.00529126
Score: 0.956
Data Source: STRINGDB
EIF2S2
Novelty: 0.0146918
Score: 0.951
Data Source: Reactome,STRINGDB
RPS28
Novelty: 0.03303065
Score: 0.948
Data Source: STRINGDB
RPL11
Novelty: 0.00448962
Score: 0.947
Data Source: STRINGDB
RPL10A
Novelty: 0.01747453
Score: 0.943
Data Source: STRINGDB
EIF2S1
Novelty: 0.00076124
Score: 0.932
Data Source: Reactome,STRINGDB
RPS23
Novelty: 0.01846154
Score: 0.925
Data Source: STRINGDB
DHX9
Family: Enzyme
Novelty: 0.00130907
Score: 0.924
Data Source: STRINGDB
RPL8
Novelty: 0.01064076
Score: 0.915
Data Source: STRINGDB
Publication Statistics
PubMed Score 26.20
PubMed score by year
PubTator Score 19.01
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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