Tbio ABCF1 ATP-binding cassette sub-family F member 1

Protein Summary

Description

Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains which are characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the inflammation process. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NE71
• A2BF75
• O14897
• Q69YP6

Gene Name

• ABCF1

Ensembl ID

• ENST00000326195
• ENSP00000313603
• ENSG00000204574
• ENST00000376545
• ENSP00000365728
• ENST00000383587
• ENSP00000373081
• ENSG00000206490
• ENST00000383588
• ENSP00000373082
• ENST00000412443
• ENSP00000404726
• ENSG00000236342
• ENST00000419893
• ENSP00000389065
• ENSG00000232169
• ENST00000420257
• ENSP00000391102
• ENSG00000225989
• ENST00000421042
• ENSP00000393143
• ENSG00000231129
• ENST00000423247
• ENSP00000411327
• ENST00000426219
• ENSP00000414373
• ENST00000448939
• ENSP00000403526
• ENST00000452530
• ENSP00000389472
• ENSG00000236149
• ENST00000457078
• ENSP00000412553
• ENST00000457111
• ENSP00000413319

Symbol

• ABC50
• ABC27
• ABC50

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
drug perturbation	1
interacting protein	0.99
molecular function	0.96
kinase perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Transporter / Atp-binding Cassette (Abc) Transporter / Atp-binding Cassette Sub-family F Member 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Atp-binding Cassette Sub-family F Member 1

Protein / Hydrolase / Atp-binding Cassette Sub-family F Member 1

DTO Classes

Protein / Enzyme / Hydrolase / Atp-binding Cassette Sub-family F Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0