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Tchem
HIPK4
Homeodomain-interacting protein kinase 4

Protein Summary
Description
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291823
  • ENSP00000291823
  • ENSG00000160396
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
1
molecular function
0.91
protein domain
0.73
cell line
0.53
cell type or tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sorafenib
chemical structure image
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (25)
1 – 10 of 25
PLD3
Tbio
Family: Enzyme
Novelty: 0.01610007
Score: 0.908
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.907
Data Source: STRINGDB
RASSF5
Tbio
Novelty: 0.01035881
Score: 0.806
Data Source: STRINGDB
APPBP2
Tbio
Novelty: 0.14742368
Score: 0.73
Data Source: STRINGDB
FGL1
Tbio
Novelty: 0.02650803
Score: 0.709
Data Source: STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
Score: 0.684
Data Source: STRINGDB
ZNF146
Tbio
Family: TF
Novelty: 0.05977172
Score: 0.649
Data Source: STRINGDB
TTC9B
Tdark
Novelty: 0.25942345
Score: 0.6
Data Source: STRINGDB
DMAC2
Tbio
Family: Enzyme
Novelty: 0.76547166
Score: 0.557
Data Source: STRINGDB
IRGQ
Tdark
Family: Enzyme
Novelty: 0.9065415
Score: 0.55
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.61

PubMed score by year
PubTator Score  3.08

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer