You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HIPK4
Homeodomain-interacting protein kinase 4

Protein Summary
Description
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291823
  • ENSP00000291823
  • ENSG00000160396
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule
1
molecular function
0.91
protein domain
0.73
cell line
0.53
cell type or tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (25)
PLD3
Tbio
Family:  Enzyme
Novelty:  0.01610007
Score:  0.908
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.907
Data Source:  STRINGDB
RASSF5
Tbio
Novelty:  0.01035881
Score:  0.806
Data Source:  STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
Score:  0.73
Data Source:  STRINGDB
FGL1
Tbio
Novelty:  0.02650803
Score:  0.709
Data Source:  STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
Score:  0.684
Data Source:  STRINGDB
ZNF146
Tbio
Family:  TF
Novelty:  0.05977172
Score:  0.649
Data Source:  STRINGDB
TTC9B
Tdark
Novelty:  0.25942345
Score:  0.6
Data Source:  STRINGDB
DMAC2
Tbio
Family:  Enzyme
Novelty:  0.76547166
Score:  0.557
Data Source:  STRINGDB
IRGQ
Tdark
Family:  Enzyme
Novelty:  0.9065415
Score:  0.55
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
71.6
reticulocyte measurement
3
1
3
69.3
mean reticulocyte volume
1
2
2
63
lymphocyte percentage of leukocytes
1
2
2
49.1
monocyte percentage of leukocytes
1
1
1
32.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
71.6
reticulocyte measurement
3
69.3
mean reticulocyte volume
2
63
lymphocyte percentage of leukocytes
2
49.1
monocyte percentage of leukocytes
1
32.7
Find similar targets by:
IDG Resources
Chemical Tool
N,1,4,4-tetramethyl-8-((2-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
image for N,1,4,4-tetramethyl-8-((2-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide
Details:
  • ChEBI:  144673
  • Provider:  UNC-CH
  • Activity:  655 nM
  • Selectivity:  0.02
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
homeodomain interacting protein kinase 4
VGNC:2341
468883
Macaque
homeodomain interacting protein kinase 4
701317
Mouse
MGI:2685008
233020
Rat
RGD:1307541
308449
Horse
homeodomain interacting protein kinase 4
VGNC:18794
100068062
Species
Name
OMA
EggNOG
Inparanoid
Chimp
homeodomain interacting protein kinase 4
Macaque
homeodomain interacting protein kinase 4
Mouse
Rat
Horse
homeodomain interacting protein kinase 4
Publication Statistics
PubMed Score 4.61
PubMed score by year
PubTator Score 3.08
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title