Tbio CHDH Choline dehydrogenase, mitochondrial

Protein Summary

Description

The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q8NE62
• Q9NY17
• CDH

Gene Name

• CHDH

Ensembl ID

• ENST00000315251
• ENSP00000319851
• ENSG00000016391

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.88
kinase perturbation	0.84
histone modification site profile	0.7
cell type or tissue	0.66
transcription factor perturbation	0.61

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Choline Dehydrogenase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Choline Dehydrogenase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.83   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.83   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0