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Tdark
STKLD1
Serine/threonine kinase-like domain-containing protein STKLD1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371957
  • ENSP00000361025
  • ENSG00000198870
  • ENST00000627962
  • ENSP00000486786
  • ENSG00000281245

Symbol
  • C9orf96
  • SGK071
  • Sk521
  • SgK071
  • C9orf96
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cellular component
0.84
tissue sample
0.61
transcription factor
0.59
transcription factor binding site profile
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (16)
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.998865713
p_ni:  0.000082889
p_wrong:  0.001051398
Score:  0.538
Data Source:  BioPlex,STRINGDB
PSMD12
Tbio
Family:  Enzyme
Novelty:  0.03178037
p_int:  0.995163463
p_ni:  0.004686151
p_wrong:  0.000150385
Score:  0.692
Data Source:  BioPlex,STRINGDB
NCBP1
Tbio
Novelty:  0.01228885
Score:  0.835
Data Source:  STRINGDB
IMPDH2
Tclin
Family:  Enzyme
Novelty:  0.00815361
Score:  0.816
Data Source:  STRINGDB
TPK1
Tbio
Family:  Kinase
Novelty:  0.00899463
Score:  0.616
Data Source:  STRINGDB
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
Score:  0.609
Data Source:  STRINGDB
PANK4
Tbio
Family:  Kinase
Novelty:  0.14150809
Score:  0.546
Data Source:  STRINGDB
MYBPHL
Tdark
Novelty:  0.31786873
Score:  0.536
Data Source:  STRINGDB
EXOSC10
Tbio
Novelty:  0.00335571
Score:  0.532
Data Source:  STRINGDB
CEP126
Tdark
Novelty:  0.25270575
Score:  0.527
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (122)
Items per page:
1 – 5 of 122
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
8
19
2.9
98.5
low density lipoprotein cholesterol measurement
7
8
19
2.9
98.5
total cholesterol measurement
7
9
20
3
98.3
total cholesterol measurement
7
9
20
3
98.3
alkaline phosphatase measurement
4
4
5
5.9
97.8
Items per page:
1 – 5 of 122
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
19
2.9
98.5
low density lipoprotein cholesterol measurement
19
2.9
98.5
total cholesterol measurement
20
3
98.3
total cholesterol measurement
20
3
98.3
alkaline phosphatase measurement
5
5.9
97.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 1.08
PubMed score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title