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Tbio
RGS22
Regulator of G-protein signaling 22

Protein Summary
Description
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360863
  • ENSP00000354109
  • ENSG00000132554
  • ENST00000519725
  • ENSP00000427798
  • ENST00000523437
  • ENSP00000428212

Symbol
  • CT145
  • PRTD-NY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.7
cell type or tissue
0.62
histone modification site profile
0.58
tissue sample
0.53
tissue
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.07   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.07   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
1
1.3
95.6
keratinocyte carcinoma
1
1
0
1.1
80.7
balding measurement
1
1
1
68.8
non-melanoma skin carcinoma
1
1
0
1.2
56.8
lymphocyte percentage of leukocytes
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.3
95.6
keratinocyte carcinoma
0
1.1
80.7
balding measurement
1
68.8
non-melanoma skin carcinoma
0
1.2
56.8
lymphocyte percentage of leukocytes
1
6.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 22
VGNC:2454
464312
Mouse
MGI:3613651
626596
Rat
RGD:1565493
500853
Dog
regulator of G protein signaling 22
VGNC:45532
475046
Horse
regulator of G protein signaling 22
VGNC:22351
100061011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 22
Mouse
Rat
Dog
regulator of G protein signaling 22
Horse
regulator of G protein signaling 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NE09-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (46)
1 – 10 of 46
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.9
Data Source:  STRINGDB
GNAI1
Tbio
Novelty:  0.0488971
Score:  0.9
Data Source:  STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
Score:  0.9
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.9
Data Source:  STRINGDB
ODF4
Tbio
Novelty:  0.13423621
Score:  0.654
Data Source:  STRINGDB
FBXO39
Tbio
Novelty:  0.05342001
Score:  0.651
Data Source:  STRINGDB
MAP1S
Tbio
Novelty:  0.02643414
Score:  0.63
Data Source:  STRINGDB
FBXO43
Tbio
Novelty:  0.04056148
Score:  0.57
Data Source:  STRINGDB
CABCOCO1
Tdark
Novelty:  0.41263041
Score:  0.512
Data Source:  STRINGDB
CEP78
Tbio
Novelty:  0.12637977
Score:  0.508
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.07

PubMed score by year
PubTator Score  3.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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