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Tbio
C3orf58
Deleted in autism protein 1

Protein Summary
Description
May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315691
  • ENSP00000320081
  • ENSG00000181744
  • ENST00000495414
  • ENSP00000417382

Symbol
  • DIA1
  • DIA1
  • HASF
  • C3orf58
  • GoPro49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (73)
1 – 10 of 73
GOLPH3L
Tbio
Novelty:  0.30373124
p_int:  0.98866162
p_ni:  0.009941609
p_wrong:  0.001396771
Score:  0.252
Data Source:  BioPlex,STRINGDB
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.967827132
p_ni:  0.032171196
p_wrong:  0.000001672
Score:  0.407
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.880900222
p_ni:  0.119099778
Data Source:  BioPlex
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.750168375
p_ni:  0.249831617
p_wrong:  8e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.909
Data Source:  STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.901
Data Source:  STRINGDB
SEC24D
Tbio
Novelty:  0.04795527
Score:  0.9
Data Source:  STRINGDB
SEC24B
Tbio
Novelty:  0.01031644
Score:  0.9
Data Source:  STRINGDB
PEF1
Tbio
Novelty:  0.01442356
Score:  0.9
Data Source:  STRINGDB
SEC24A
Tbio
Novelty:  0.07724534
Score:  0.9
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
2
2
67.5
mathematical ability
3
3
3
54.3
self reported educational attainment
1
1
1
7.1
smoking status measurement
1
1
1
4.8
cognitive function measurement
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
67.5
mathematical ability
3
54.3
self reported educational attainment
1
7.1
smoking status measurement
1
4.8
cognitive function measurement
1
2
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromosome 3 C3orf58 homolog
VGNC:5031
460752
Macaque
chromosome 2 open reading frame, human C3orf58
713830
Mouse
MGI:1916111
68861
Rat
RGD:1309079
315891
Dog
chromosome 23 C3orf58 homolog
VGNC:52527
611428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromosome 3 C3orf58 homolog
Macaque
chromosome 2 open reading frame, human C3orf58
Mouse
Rat
Dog
chromosome 23 C3orf58 homolog
Publication Statistics
PubMed Score 25.30
PubMed score by year
PubTator Score 8.82
PubTator score by year