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Tdark
BHLHE23
Class E basic helix-loop-helix protein 23

Protein Summary
Description
May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and neuronal cell types. May be important for rod bipolar cell maturation (By similarity). This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370346
  • ENSP00000359371
  • ENSG00000125533

Symbol
  • BHLHB4
  • BETA4
  • BHLHB4
  • Beta3b
  • bA305P22.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
tissue
0.76
cell type or tissue
0.65
PubMedID
0.54
transcription factor binding site profile
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.37   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.37   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.752
Data Source:  STRINGDB
VSX1
Tbio
Family:  TF
Novelty:  0.01213324
Score:  0.743
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.628
Data Source:  STRINGDB
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
Score:  0.574
Data Source:  STRINGDB
IRX5
Tbio
Family:  TF
Novelty:  0.02583962
Score:  0.547
Data Source:  STRINGDB
PCP2
Tdark
Novelty:  0.05083955
Score:  0.539
Data Source:  STRINGDB
TAL2
Tbio
Family:  TF
Novelty:  0.03960914
Score:  0.538
Data Source:  STRINGDB
SEBOX
Tbio
Family:  TF
Novelty:  0.12741718
Score:  0.532
Data Source:  STRINGDB
CABP5
Tbio
Novelty:  0.10488887
Score:  0.503
Data Source:  STRINGDB
FOXN4
Tbio
Family:  TF
Novelty:  0.04762528
Score:  0.501
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
48.5
age at menopause
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
48.5
age at menopause
1
42.3
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member e23
VGNC:6050
469998
Mouse
MGI:2153710
140489
Rat
RGD:1559760
499952
Cow
basic helix-loop-helix family member e23
VGNC:26485
539207
Platypus
basic helix-loop-helix family member e23
100074318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basic helix-loop-helix family member e23
Mouse
Rat
Cow
basic helix-loop-helix family member e23
Platypus
basic helix-loop-helix family member e23
Publication Statistics
PubMed Score 44.37
PubMed score by year
PubTator Score 3.65
PubTator score by year
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Related Publications
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PMID
Year
Title