Tbio ADPRHL1 [Protein ADP-ribosylarginine] hydrolase-like protein 1

Protein Summary

Description

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed 12070318]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NDY3
• Q5JUG2
• Q96GD1

Gene Name

• ADPRHL1

Ensembl ID

• ENST00000356501
• ENSP00000348894
• ENSG00000153531
• ENST00000375418
• ENSP00000364567

Symbol

• ARH2
• ARH2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.66
gene perturbation	0.53
cell line	0.52
tissue sample	0.52
cell type or tissue	0.47

Protein Classes

PANTHER Classes

Protein / Hydrolase / [Protein Adp-ribosylarginine] Hydrolase-like Protein 1

DTO Classes

Protein / Enzyme / Hydrolase / [Protein Adp-ribosylarginine] Hydrolase-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.66   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0