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Tbio
SLC17A8
Vesicular glutamate transporter 3

Protein Summary
Description
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323346
  • ENSP00000316909
  • ENSG00000179520
  • ENST00000392989
  • ENSP00000376715

Symbol
  • VGLUT3
  • DFNA25
  • VGLUT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.63
cellular component
0.59
cell line
0.51
cell type or tissue
0.51
disease
0.5


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.79   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.79   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
67.4
C-reactive protein measurement
1
1
1
56.9
1
1
0
1.3
13.1
total cholesterol measurement
1
1
1
7.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
67.4
C-reactive protein measurement
1
56.9
0
1.3
13.1
total cholesterol measurement
1
7.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 8
VGNC:8537
452161
Macaque
solute carrier family 17 member 8
695508
Mouse
MGI:3039629
216227
Rat
RGD:628870
266767
Dog
solute carrier family 17 member 8
VGNC:46253
482623
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 17 member 8
Macaque
solute carrier family 17 member 8
Mouse
Rat
Dog
solute carrier family 17 member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NDX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) (R-HSA-5619076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Organic anion transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)
Disease
Disorders of transmembrane transporters
Organic anion transporters
SLC transporter disorders
Protein-Protein Interactions (92)
1 – 10 of 92
RHBDD1
Tbio
Family: Enzyme
Novelty: 0.10354568
p_int: 0.993431267
p_ni: 0.006566157
p_wrong: 0.000002576
Data Source: BioPlex
SARAF
Tbio
Novelty: 0.0383833
p_int: 0.972767458
p_ni: 0.027168484
p_wrong: 0.000064058
Data Source: BioPlex
SLC32A1
Tchem
Family: Transporter
Novelty: 0.00237273
Score: 0.959
Data Source: STRINGDB
SLC18A3
Tchem
Family: Transporter
Novelty: 0.00169007
Score: 0.954
Data Source: STRINGDB
SLC18A2
Tclin
Family: Transporter
Novelty: 0.00072341
Score: 0.916
Data Source: STRINGDB
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
Score: 0.87
Data Source: STRINGDB
SLC17A6
Tbio
Family: Transporter
Novelty: 0.00163193
Score: 0.811
Data Source: STRINGDB
SLC17A7
Tbio
Family: Transporter
Novelty: 0.00165722
Score: 0.806
Data Source: STRINGDB
ANO4
Tbio
Novelty: 0.10053632
Score: 0.801
Data Source: STRINGDB
FAM19A4
Tbio
Novelty: 0.04305684
Score: 0.789
Data Source: STRINGDB
Publication Statistics
PubMed Score  164.79

PubMed score by year
PubTator Score  41.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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