PSD4
PH and SEC7 domain-containing protein 4
Protein Summary
Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate.
- ENST00000245796
- ENSP00000245796
- ENSG00000125637
- ENST00000441564
- ENSP00000413997
- EFA6B
- TIC
- TIC
- EFA6B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.74 | ||
protein domain | 0.73 | ||
tissue sample | 0.64 | ||
co-expressed gene | 0.61 | ||
transcription factor | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.07 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 53 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 15.07 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 53 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (35)
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (46)
Items per page:
1 – 5 of 46
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 7 | 8 | 11 | 99.2 | |||||
hematocrit | 3 | 3 | 3 | 95.4 | |||||
lymphocyte count | 3 | 3 | 3 | 92.1 | |||||
hemoglobin measurement | 3 | 2 | 3 | 92 | |||||
blood urea nitrogen measurement | 3 | 2 | 3 | 91 | |||||
Items per page:
1 – 5 of 46
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 11 | 99.2 | |||||
hematocrit | 3 | 95.4 | |||||
lymphocyte count | 3 | 92.1 | |||||
hemoglobin measurement | 3 | 92 | |||||
blood urea nitrogen measurement | 3 | 91 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | pleckstrin and Sec7 domain containing 4 | VGNC:344 | 459502 | |||||
Macaque | pleckstrin and Sec7 domain containing 4 | 701785 | ||||||
Mouse | MGI:2674093 | 215632 | ||||||
Rat | RGD:1310289 | 311785 | ||||||
Dog | pleckstrin and Sec7 domain containing 4 | VGNC:45084 | 483069 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | pleckstrin and Sec7 domain containing 4 | |||||
Macaque | pleckstrin and Sec7 domain containing 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | pleckstrin and Sec7 domain containing 4 | |||||
Publication Statistics
PubMed Score 15.07
PubMed score by year
PubTator Score 56.63
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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