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Tbio
ST6GALNAC3
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Protein Summary
Description
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328299
  • ENSP00000329214
  • ENSG00000184005

Symbol
  • SIAT7C
  • STY
  • SIAT7C
  • PRO7177
  • ST6GALNACIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
microRNA
0.79
histone modification site profile
0.75
phenotype
0.74
tissue sample
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
HFE
Tbio
Novelty:  0.00042077
p_int:  0.996746627
p_ni:  0.002508775
p_wrong:  0.000744598
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.996726411
p_ni:  0.003227269
p_wrong:  0.00004632
Data Source:  BioPlex
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
p_int:  0.995332093
p_ni:  0.004667907
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.994633851
p_ni:  0.001223584
p_wrong:  0.004142565
Data Source:  BioPlex
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.992949934
p_ni:  0.007010472
p_wrong:  0.000039595
Data Source:  BioPlex
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.991930697
p_ni:  0.008069303
Score:  0.198
Data Source:  BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.984860408
p_ni:  0.015062245
p_wrong:  0.000077347
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.937134491
p_ni:  0.062735066
p_wrong:  0.000130443
Data Source:  BioPlex
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.928977092
p_ni:  0.071022908
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.874510137
p_ni:  0.003872776
p_wrong:  0.121617087
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
39.6
childhood trauma measurement
1
1
1
21.5
cognitive function measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
39.6
childhood trauma measurement
1
21.5
cognitive function measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
VGNC:10961
450115
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
709779
Mouse
MGI:1341828
20447
Rat
RGD:3677
29758
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
VGNC:46859
490205
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Macaque
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Mouse
Rat
Dog
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Publication Statistics
PubMed Score 11.09
PubMed score by year
PubTator Score 6.72
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title