Tbio ST6GALNAC3 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

Protein Summary

Description

Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins (By similarity). ST6GALNAC3 belongs to a family of sialyltransferases that transfer sialic acids from CMP-sialic acid to terminal positions of carbohydrate groups in glycoproteins and glycolipids (Lee et al., 1999 [PubMed 10207017]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8NDV1
• Q6PCE0
• Q6UX29
• Q8N259

Gene Name

• ST6GALNAC3

Ensembl ID

• ENST00000328299
• ENSP00000329214
• ENSG00000184005

Symbol

• SIAT7C
• STY
• SIAT7C
• PRO7177
• ST6GALNACIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
microRNA	0.79
histone modification site profile	0.75
phenotype	0.74
tissue sample	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.83   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0