Tbio AGBL5 Cytosolic carboxypeptidase-like protein 5

Protein Summary

Description

Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q8NDL9
• A2VDI7
• B7WPG9
• B7Z7I7
• D6W548
• Q53SW0
• Q53SZ0
• Q96IK8
• Q9H6V0
• Q9H8P8

Gene Name

• AGBL5

Ensembl ID

• ENST00000323064
• ENSP00000323681
• ENSG00000084693
• ENST00000360131
• ENSP00000353249
• ENST00000487078
• ENSP00000433830

Symbol

• CCP5
• CCP5
• RP75

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
histone modification site profile	0.83
kinase perturbation	0.81
transcription factor perturbation	0.8
virus perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Cytosolic Carboxypeptidase-like Protein 5

Protein / ... / Metalloprotease / Cytosolic Carboxypeptidase-like Protein 5

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Cytosolic Carboxypeptidase-like Protein 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.82   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.82   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0