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Tbio
AGBL5
Cytosolic carboxypeptidase-like protein 5

Protein Summary
Description
Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323064
  • ENSP00000323681
  • ENSG00000084693
  • ENST00000360131
  • ENSP00000353249
  • ENST00000487078
  • ENSP00000433830

Symbol
  • CCP5
  • CCP5
  • RP75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
histone modification site profile
0.83
kinase perturbation
0.81
transcription factor perturbation
0.8
virus perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.53   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.53   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
78.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP/GTP binding protein like 5
VGNC:50335
459092
Macaque
ATP/GTP binding protein like 5
697940
Mouse
MGI:2441745
231093
Rat
RGD:1598311
362710
Dog
ATP/GTP binding protein like 5
VGNC:37698
475695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP/GTP binding protein like 5
Macaque
ATP/GTP binding protein like 5
Mouse
Rat
Dog
ATP/GTP binding protein like 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NDL9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (37)
1 – 10 of 37
TPCN2
Tchem
Family: IC
Novelty: 0.01351129
p_int: 0.999997229
p_ni: 0.000002771
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00155885
p_int: 0.999878422
p_ni: 0.000121551
p_wrong: 2.7e-8
Data Source: BioPlex
RELL2
Tbio
Novelty: 0.59290726
p_int: 0.999852607
p_ni: 0.000146216
p_wrong: 0.000001177
Score: 0.189
Data Source: BioPlex,STRINGDB
GFOD1
Tdark
Family: Enzyme
Novelty: 0.35031766
p_int: 0.993786703
p_ni: 0.006211955
p_wrong: 0.000001341
Score: 0.209
Data Source: BioPlex,STRINGDB
IL20RA
Tbio
Novelty: 0.02416816
p_int: 0.861817817
p_ni: 0.00093798
p_wrong: 0.137244203
Score: 0.175
Data Source: BioPlex,STRINGDB
EIF4G3
Tbio
Novelty: 0.03002723
Score: 0.69
Data Source: STRINGDB
DEAF1
Tbio
Family: TF
Novelty: 0.01070035
Score: 0.682
Data Source: STRINGDB
TTLL6
Tdark
Family: Enzyme
Novelty: 0.15224272
Score: 0.666
Data Source: STRINGDB
EVA1A
Tbio
Novelty: 0.02121024
Score: 0.651
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.636
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.53

PubMed score by year
PubTator Score  10.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer