You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TDRD9
ATP-dependent RNA helicase TDRD9

Protein Summary
Description
ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409874
  • ENSP00000387303
  • ENSG00000156414

Symbol
  • C14orf75
  • HLS
  • SPNE
  • HIG-1
  • NET54
  • SPGF30
  • C14orf75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
gene perturbation
0.86
protein domain
0.85
cell type or tissue
0.77
cellular component
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
1
1
6.3
74.5
unipolar depression
1
1
0
1
37.5
Myopia
1
1
0
6.3
31.1
age at onset
1
1
0
6.3
31.1
1
1
0
1.1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
6.3
74.5
unipolar depression
0
1
37.5
Myopia
0
6.3
31.1
age at onset
0
6.3
31.1
0
1.1
3.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 9
VGNC:3305
453195
Macaque
tudor domain containing 9
701635
Mouse
MGI:1921941
74691
Rat
RGD:1306942
299343
Dog
tudor domain containing 9
VGNC:47226
100687431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 9
Macaque
tudor domain containing 9
Mouse
Rat
Dog
tudor domain containing 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NDG6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (17)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (65)
1 – 10 of 65
PIWIL4
Tbio
Novelty: 0.00105088
Score: 0.991
Data Source: Reactome,STRINGDB
MOV10L1
Tbio
Family: Enzyme
Novelty: 0.09735465
Score: 0.99
Data Source: STRINGDB
MAEL
Tbio
Novelty: 0.01925239
Score: 0.99
Data Source: Reactome,STRINGDB
PIWIL2
Tbio
Novelty: 0.00907402
Score: 0.987
Data Source: STRINGDB
TDRD12
Tdark
Family: Epigenetic
Novelty: 0.2276017
Score: 0.985
Data Source: STRINGDB
TDRD5
Tdark
Family: Epigenetic
Novelty: 0.115495
Score: 0.98
Data Source: STRINGDB
ASZ1
Tbio
Novelty: 0.0011137
Score: 0.977
Data Source: STRINGDB
DDX4
Tbio
Family: Enzyme
Novelty: 0.00692586
Score: 0.973
Data Source: STRINGDB
TDRD1
Tbio
Family: Epigenetic
Novelty: 0.04645566
Score: 0.965
Data Source: STRINGDB
HENMT1
Tdark
Family: Enzyme
Novelty: 0.17427834
Score: 0.964
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  8.30

PubMed score by year
PubTator Score  2.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: