Tbio TENT4B Non-canonical poly(A) RNA polymerase PAPD5

Protein Summary

Description

Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037).

Uniprot Accession IDs

• Q8NDF8
• B4DV38
• Q9NW67
• Q9Y6C0

Gene Name

• TENT4B

Ensembl ID

• ENST00000436909
• ENSP00000396995
• ENSG00000121274

Symbol

• GLD4
• PAPD5
• TRF4-2
• TUT3
• PAPD5
• TRF4-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
kinase perturbation	0.84
microRNA	0.73
molecular function	0.67
cell type or tissue	0.59

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Non-canonical Poly(a) Rna Polymerase Papd5

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna-directed Dna Polymerase / Non-canonical Poly(a) Rna Polymerase Papd5

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Non-canonical Poly(a) Rna Polymerase Papd5

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Polymerase / Dna-directed Dna Polymerase / Non-canonical Poly(a) Rna Polymerase Papd5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.08   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 145   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.08   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0