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Tbio
TENT4B
Non-canonical poly(A) RNA polymerase PAPD5

Protein Classes
Protein Summary
Description
Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the ex ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000436909
  • ENSP00000396995
  • ENSG00000121274

Symbol
  • GLD4
  • PAPD5
  • TRF4-2
  • TUT3
  • PAPD5
  • TRF4-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
kinase perturbation
0.84
microRNA
0.73
molecular function
0.67
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.63   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.63   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
42
forced expiratory volume
1
1
1
16.7
lymphocyte percentage of leukocytes
1
1
1
7.8
birth weight
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
42
forced expiratory volume
1
16.7
lymphocyte percentage of leukocytes
1
7.8
birth weight
1
1.9
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (104)
1 – 10 of 104
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.999126966
p_ni: 0.000873034
Data Source: BioPlex
PPAN
Tbio
Novelty: 0.01063709
p_int: 0.991395834
p_ni: 0.008604166
Score: 0.252
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.98684512
p_ni: 0.01315488
Score: 0.228
Data Source: BioPlex,STRINGDB
NPM1
Tbio
Novelty: 0.0005485
p_int: 0.969039834
p_ni: 0.030960166
Score: 0.239
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.949898601
p_ni: 0.050101399
Score: 0.661
Data Source: BioPlex,STRINGDB
ZNF2
Tbio
Family: TF
Novelty: 0.01062543
p_int: 0.929409807
p_ni: 0.070590193
Score: 0.26
Data Source: BioPlex,STRINGDB
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.916320398
p_ni: 0.083679602
Data Source: BioPlex
ZC3HAV1
Tbio
Novelty: 0.01357759
p_int: 0.855126382
p_ni: 0.144873618
Score: 0.632
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.829291832
p_ni: 0.170708168
Score: 0.263
Data Source: BioPlex,STRINGDB
RBM28
Tbio
Novelty: 0.13090674
p_int: 0.81703268
p_ni: 0.18296732
Data Source: BioPlex
Publication Statistics
PubMed Score  14.63

PubMed score by year
PubTator Score  7.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer