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Tbio
PPFIBP2
Liprin-beta-2

Protein Summary
Description
May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299492
  • ENSP00000299492
  • ENSG00000166387
  • ENST00000528883
  • ENSP00000435469
  • ENST00000530181
  • ENSP00000437321

Symbol
  • Cclp1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.8
transcription factor binding site profile
0.79
virus perturbation
0.79
PubMedID
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.13   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.13   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
Score:  0.97
Data Source:  Reactome,STRINGDB
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
Score:  0.963
Data Source:  Reactome,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
Score:  0.959
Data Source:  Reactome,STRINGDB
OVCH2
Tdark
Family:  Enzyme
Novelty:  0.32719563
Score:  0.741
Data Source:  STRINGDB
TCFL5
Tbio
Family:  TF
Novelty:  0.00483499
Score:  0.661
Data Source:  STRINGDB
OLFML1
Tdark
Novelty:  0.27791923
Score:  0.592
Data Source:  STRINGDB
PPFIA1
Tbio
Novelty:  0.01904029
Score:  0.59
Data Source:  STRINGDB
PPFIA3
Tbio
Novelty:  0.03837299
Score:  0.57
Data Source:  STRINGDB
PPFIA2
Tbio
Novelty:  0.13312014
Score:  0.556
Data Source:  STRINGDB
GRIP1
Tbio
Novelty:  0.00343871
Score:  0.509
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
2
0
1.1
94.5
hair colour measurement
1
1
1
92.8
1
1
0
1.2
39.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
94.5
hair colour measurement
1
92.8
0
1.2
39.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PPFIA binding protein 2
VGNC:7661
749024
Macaque
PPFIA binding protein 2
707763
Mouse
MGI:894649
19024
Rat
RGD:1565383
308918
Dog
PPFIA binding protein 2
VGNC:44848
485366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PPFIA binding protein 2
Macaque
PPFIA binding protein 2
Mouse
Rat
Dog
PPFIA binding protein 2
Publication Statistics
PubMed Score 21.13
PubMed score by year
PubTator Score 11.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title