Tbio PPFIBP2 Liprin-beta-2

Protein Summary

Description

May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A. This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q8ND30
• B7Z433
• E9PK77
• O75337
• Q8WW26

Gene Name

• PPFIBP2

Ensembl ID

• ENST00000299492
• ENSP00000299492
• ENSG00000166387
• ENST00000528883
• ENSP00000435469
• ENST00000530181
• ENSP00000437321

Symbol

• Cclp1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
histone modification site profile	0.8
transcription factor binding site profile	0.79
virus perturbation	0.79
PubMedID	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.13   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.13   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0