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Tdark
SMG8
Protein SMG8

Protein Summary
Description
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300917
  • ENSP00000300917
  • ENSG00000167447
  • ENST00000543872
  • ENSP00000438748
  • ENST00000578922
  • ENSP00000462119

Symbol
  • ABC2
  • C17orf71
  • C17orf71
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
histone modification site profile
0.71
tissue
0.66
transcription factor binding site profile
0.66
tissue sample
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
68.6
myeloperoxidase measurement
1
1
1
53.7
HbA1c measurement
1
1
1
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
68.6
myeloperoxidase measurement
1
53.7
HbA1c measurement
1
7.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SMG8, nonsense mediated mRNA decay factor
VGNC:12679
468293
Mouse
MGI:1921383
74133
Rat
RGD:1306862
287596
Dog
SMG8, nonsense mediated mRNA decay factor
491116
Horse
SMG8, nonsense mediated mRNA decay factor
100057203
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SMG8, nonsense mediated mRNA decay factor
Mouse
Rat
Dog
SMG8, nonsense mediated mRNA decay factor
Horse
SMG8, nonsense mediated mRNA decay factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8ND04-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (149)
1 – 10 of 149
LRRC49
Tdark
Novelty:  0.19477281
p_int:  0.99998614
p_ni:  0.00001386
Score:  0.558
Data Source:  BioPlex,STRINGDB
NICN1
Tdark
Novelty:  0.32909597
p_int:  0.998975645
p_ni:  0.001024355
Score:  0.775
Data Source:  BioPlex,STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.998817515
p_ni:  0.001182485
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.993861295
p_ni:  0.006138621
p_wrong:  8.4e-8
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.993361195
p_ni:  0.006638805
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.987962873
p_ni:  0.011624281
p_wrong:  0.000412846
Data Source:  BioPlex
DRC3
Tdark
Novelty:  0.99283468
p_int:  0.979689929
p_ni:  0.020309838
p_wrong:  2.34e-7
Data Source:  BioPlex
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.977185293
p_ni:  0.022814707
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.96795942
p_ni:  0.032040579
p_wrong:  1e-9
Data Source:  BioPlex
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.952714648
p_ni:  0.047285352
Data Source:  BioPlex
Publication Statistics
PubMed Score  4.89

PubMed score by year
PubTator Score  4.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer