Tbio SMG8 Protein SMG8

Protein Summary

Description

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.

Uniprot Accession IDs

• Q8ND04
• Q8N5U5
• Q8TDN0
• Q9H5P5
• Q9NVQ1

Gene Name

• SMG8

Ensembl ID

• ENST00000300917
• ENSP00000300917
• ENSG00000167447
• ENST00000543872
• ENSP00000438748
• ENST00000578922
• ENSP00000462119

Symbol

• ABC2
• C17orf71
• C17orf71

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.9
histone modification site profile	0.71
tissue	0.66
transcription factor binding site profile	0.66
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.4   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 46   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.4   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0