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Tbio
KREMEN2
Kremen protein 2

Protein Classes
Protein Summary
Description
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303746
  • ENSP00000304422
  • ENSG00000131650
  • ENST00000319500
  • ENSP00000322079
  • ENST00000571007
  • ENSP00000461860
  • ENST00000572045
  • ENSP00000460578
  • ENST00000575769
  • ENSP00000460917
  • ENST00000575885
  • ENSP00000459878

Symbol
  • KRM2
  • KRM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.73
transcription factor binding site profile
0.67
small molecule perturbation
0.65
PubMedID
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kringle containing transmembrane protein 2
701257
Mouse
MGI:1920266
73016
Rat
RGD:1310795
287102
Dog
kringle containing transmembrane protein 2
VGNC:42512
610753
Cow
kringle containing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:18797]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kringle containing transmembrane protein 2
Mouse
Rat
Dog
kringle containing transmembrane protein 2
Cow
kringle containing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:18797]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NCW0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Reactome
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Signal Transduction
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (24)
1 – 10 of 24
DKK1
Tchem
Novelty: 0.00117121
Score: 0.971
Data Source: Reactome,STRINGDB
LRP5
Tbio
Novelty: 0.00089807
Score: 0.968
Data Source: Reactome,STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.967
Data Source: Reactome,STRINGDB
DKK2
Tbio
Novelty: 0.01445201
Score: 0.961
Data Source: STRINGDB
WNT1
Tbio
Novelty: 0.00124301
Score: 0.951
Data Source: STRINGDB
DKK4
Tbio
Novelty: 0.02793673
Score: 0.942
Data Source: STRINGDB
WNT3A
Tchem
Novelty: 0.00119275
Score: 0.938
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.937
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.922
Data Source: STRINGDB
WNT8A
Tbio
Novelty: 0.01404009
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.12

PubMed score by year
PubTator Score  5.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer