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Tdark
SLC44A5
Choline transporter-like protein 5

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Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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ARCHS4
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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
3
2
1
6
79.8
metabolite measurement
2
1
2
67.4
1
1
1
48.2
unipolar depression
1
1
1
48.2
depressive symptom measurement
1
1
1
43.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
6
79.8
metabolite measurement
2
67.4
1
48.2
unipolar depression
1
48.2
depressive symptom measurement
1
43.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 44 member 5
VGNC:6121
456953
Macaque
solute carrier family 44 member 5
704729
Mouse
MGI:3035141
242259
Rat
RGD:1564620
365962
Dog
solute carrier family 44 member 5
VGNC:46421
490208
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 44 member 5
Macaque
solute carrier family 44 member 5
Mouse
Rat
Dog
solute carrier family 44 member 5
Pathways (9)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
SLC-mediated transmembrane transport
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (45)
1 – 10 of 45
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.999936645
p_ni: 0.000057121
p_wrong: 0.000006234
Data Source: BioPlex
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.999819288
p_ni: 0.000180707
p_wrong: 5e-9
Score: 0.266
Data Source: BioPlex,STRINGDB
CLDND1
Tbio
Novelty: 0.06681793
p_int: 0.999364504
p_ni: 0.000313268
p_wrong: 0.000322228
Score: 0.167
Data Source: BioPlex,STRINGDB
OR2G6
Tdark
Family: oGPCR
p_int: 0.999191914
p_ni: 0.000334052
p_wrong: 0.000474034
Data Source: BioPlex
MOSPD2
Tbio
Novelty: 0.14602473
p_int: 0.992422553
p_ni: 0.007577198
p_wrong: 2.48e-7
Score: 0.166
Data Source: BioPlex,STRINGDB
REEP4
Tbio
Novelty: 0.37950931
p_int: 0.981596546
p_ni: 0.018403116
p_wrong: 3.38e-7
Score: 0.207
Data Source: BioPlex,STRINGDB
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.981436383
p_ni: 0.000105084
p_wrong: 0.018458533
Data Source: BioPlex
NME2P1
Tdark
Family: Kinase
p_int: 0.953472052
p_ni: 0.046527941
p_wrong: 7e-9
Data Source: BioPlex
OR10S1
Tdark
Family: oGPCR
Novelty: 2.23425255
p_int: 0.903650029
p_ni: 0.002565347
p_wrong: 0.093784623
Data Source: BioPlex
ATG9A
Tbio
Novelty: 0.01995033
p_int: 0.889382172
p_ni: 0.110617696
p_wrong: 1.32e-7
Score: 0.375
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.00

PubMed score by year
PubTator Score  3.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer