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Tbio
RNF169
E3 ubiquitin-protein ligase RNF169

Protein Summary
Description
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299563
  • ENSP00000299563
  • ENSG00000166439

Symbol
  • KIAA1991
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.95
histone modification site profile
0.86
ligand (protein) perturbation
0.83
cell line
0.63
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.57   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Protein-Protein Interactions (25)
1 – 10 of 25
DCAF7
Tbio
Novelty: 0.02609518
p_int: 0.999999885
p_ni: 1.15e-7
p_wrong: 1e-9
Score: 0.362
Data Source: BioPlex,STRINGDB
KLHDC2
Tbio
Novelty: 0.01485159
p_int: 0.999988877
p_ni: 0.000010554
p_wrong: 5.69e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
IL16
Tbio
Novelty: 0.0023276
p_int: 0.999882708
p_ni: 0.000113149
p_wrong: 0.000004143
Score: 0.416
Data Source: BioPlex,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.966
Data Source: STRINGDB
USP7
Tchem
Family: Enzyme
Novelty: 0.00412878
Score: 0.962
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.958
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.945
Data Source: STRINGDB
TP53BP1
Tbio
Family: Epigenetic
Novelty: 0.00131256
Score: 0.787
Data Source: STRINGDB
MDC1
Tbio
Novelty: 0.00533097
Score: 0.739
Data Source: STRINGDB
BRCA1
Tchem
Novelty: 0.00011146
Score: 0.707
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.57

PubMed score by year
PubTator Score  2.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer