Tbio RNF169 E3 ubiquitin-protein ligase RNF169

Protein Summary

Description

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.

Uniprot Accession IDs

• Q8NCN4
• Q6N015

Gene Name

• RNF169

Ensembl ID

• ENST00000299563
• ENSP00000299563
• ENSG00000166439

Symbol

• KIAA1991

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.95
histone modification site profile	0.86
ligand (protein) perturbation	0.83
cell line	0.63
molecular function	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.17   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0