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Tbio
DYNC2H1
Cytoplasmic dynein 2 heavy chain 1

Protein Summary
Description
May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334267
  • ENSP00000334021
  • ENSG00000187240
  • ENST00000375735
  • ENSP00000364887
  • ENST00000398093
  • ENSP00000381167
  • ENST00000649997
  • ENSP00000496872
  • ENST00000650373
  • ENSP00000497174

Symbol
  • DHC1B
  • DHC2
  • DNCH2
  • DYH1B
  • KIAA1997
  • ATD3
  • DHC2
  • DHC1b
  • DNCH2
  • DYH1B
  • SRTD3
  • SRPS2B
  • hdhc11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.93
cellular component
0.84
histone modification site profile
0.79
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.11   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.11   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
DYNC2LI1
Tbio
Novelty:  0.05087433
p_int:  0.999999995
p_ni:  5e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.999980059
p_ni:  0.000019941
Score:  0.188
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.996064354
p_ni:  0.003935646
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.989500909
p_ni:  0.010499091
Score:  0.956
Data Source:  BioPlex,STRINGDB
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.97397711
p_ni:  0.02602289
Score:  0.167
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.931951673
p_ni:  0.068048327
Data Source:  BioPlex
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
p_int:  0.898231976
p_ni:  0.101768024
Score:  0.188
Data Source:  BioPlex,STRINGDB
ARMC5
Tbio
Novelty:  0.02895521
p_int:  0.866263089
p_ni:  0.133736911
Data Source:  BioPlex
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.800172061
p_ni:  0.199827939
Score:  0.203
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.775997654
p_ni:  0.224002346
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Cilium Assembly (R-HSA-5617833)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Hedgehog 'off' state
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Hedgehog 'off' state
Intraflagellar transport
Organelle biogenesis and maintenance
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
4
5
1.1
97.7
5
4
2
1.1
93.9
angina pectoris
3
3
3
63.7
matrix metalloproteinase measurement
1
1
1
56
Vasodilators used in cardiac diseases use measurement
2
2
2
41.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
97.7
2
1.1
93.9
angina pectoris
3
63.7
matrix metalloproteinase measurement
1
56
Vasodilators used in cardiac diseases use measurement
2
41.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 2 heavy chain 1
VGNC:8301
451515
Mouse
MGI:107736
110350
Rat
RGD:71042
65209
Dog
dynein cytoplasmic 2 heavy chain 1
VGNC:40148
479461
Opossum
dynein cytoplasmic 2 heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:2962]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein cytoplasmic 2 heavy chain 1
Mouse
Rat
Dog
dynein cytoplasmic 2 heavy chain 1
Opossum
dynein cytoplasmic 2 heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:2962]
Publication Statistics
PubMed Score 97.11
PubMed score by year
PubTator Score 30.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title