Tbio DYNC2H1 Cytoplasmic dynein 2 heavy chain 1

Protein Summary

Description

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). This gene encodes a large cytoplasmic dynein protein that is involved in retrograde transport in the cilium and has a role in intraflagellar transport, a process required for ciliary/flagellar assembly. Mutations in this gene cause a heterogeneous spectrum of conditions related to altered primary cilium function and often involve polydactyly, abnormal skeletogenesis, and polycystic kidneys. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q8NCM8
• O00432
• Q16693
• Q3C1U8
• Q4AC93
• Q6ZMX7
• Q6ZUM6
• Q7Z363
• Q8N977
• Q92815
• Q9HAE4

Gene Name

• DYNC2H1

Ensembl ID

• ENST00000334267
• ENSP00000334021
• ENSG00000187240
• ENST00000375735
• ENSP00000364887
• ENST00000398093
• ENSP00000381167
• ENST00000649997
• ENSP00000496872
• ENST00000650373
• ENSP00000497174

Symbol

• DHC1B
• DHC2
• DNCH2
• DYH1B
• KIAA1997
• ATD3
• DHC2
• DHC1b
• DNCH2
• DYH1B
• SRTD3
• SRPS2B
• hdhc11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.93
cellular component	0.84
histone modification site profile	0.79
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Hydrolase / Cytoplasmic Dynein 2 Heavy Chain 1

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Cytoplasmic Dynein 2 Heavy Chain 1

DTO Classes

Protein / Enzyme / Hydrolase / Cytoplasmic Dynein 2 Heavy Chain 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.11   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.11   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0