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Tclin
KCNH5
Potassium voltage-gated channel subfamily H member 5

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322893
  • ENSP00000321427
  • ENSG00000140015
  • ENST00000394968
  • ENSP00000378419
  • ENST00000420622
  • ENSP00000395439

Symbol
  • EAG2
  • EAG2
  • hEAG2
  • H-EAG2
  • Kv10.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
trait
0.99
gene perturbation
0.85
cell type or tissue
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (50)
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.961
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.959
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.953
Data Source:  STRINGDB
CASK
Tchem
Family:  Kinase
Novelty:  0.00856437
Score:  0.751
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.747
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.747
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.747
Data Source:  STRINGDB
TRO
Tbio
Novelty:  0.02850833
Score:  0.678
Data Source:  STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
Score:  0.663
Data Source:  STRINGDB
CAMK2B
Tchem
Family:  Kinase
Novelty:  0.00793595
Score:  0.654
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
26.1
1
1
0
3.1
15.8
intelligence
1
1
1
14.2
visceral adipose tissue measurement
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
26.1
0
3.1
15.8
intelligence
1
14.2
visceral adipose tissue measurement
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 5
VGNC:7446
467476
Macaque
potassium voltage-gated channel subfamily H member 5
705368
Mouse
MGI:3584508
238271
Rat
RGD:621417
171146
Dog
potassium voltage-gated channel subfamily H member 5
VGNC:42250
490724
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 5
Macaque
potassium voltage-gated channel subfamily H member 5
Mouse
Rat
Dog
potassium voltage-gated channel subfamily H member 5
Publication Statistics
PubMed Score 27.70
PubMed score by year
PubTator Score 17.36
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title