KCNH5
Potassium voltage-gated channel subfamily H member 5
Protein Summary
Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly. This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
- ENST00000322893
- ENSP00000321427
- ENSG00000140015
- ENST00000394968
- ENSP00000378419
- ENST00000420622
- ENSP00000395439
- EAG2
- EAG2
- hEAG2
- H-EAG2
- Kv10.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
trait | 0.99 | ||
gene perturbation | 0.85 | ||
cell type or tissue | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.84 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 55 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.84 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 55 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4