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Tbio
GALNT6
Polypeptide N-acetylgalactosaminyltransferase 6

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides. This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. The encoded protein is capable of glycosylating fibronectin peptide in vitro and is expre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356317
  • ENSP00000348668
  • ENSG00000139629
  • ENST00000543196
  • ENSP00000444171

Symbol
  • GalNAcT6
  • GALNAC-T6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.86
gene perturbation
0.85
transcription factor
0.7
histone modification site profile
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.14   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
NDUFAF6
Tbio
Family:  Enzyme
Novelty:  0.07584052
p_int:  0.999996615
p_ni:  1.82e-7
p_wrong:  0.000003202
Score:  0.277
Data Source:  BioPlex,STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.999327683
p_ni:  0.000672316
Data Source:  BioPlex
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.998321453
p_ni:  0.001605329
p_wrong:  0.000073218
Score:  0.32
Data Source:  BioPlex,STRINGDB
NDUFB6
Tclin
Family:  Enzyme
Novelty:  0.075245
p_int:  0.998244852
p_ni:  0.001571114
p_wrong:  0.000184035
Score:  0.547
Data Source:  BioPlex,STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.99781235
p_ni:  0.002187649
p_wrong:  1e-9
Data Source:  BioPlex
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
p_int:  0.996140033
p_ni:  0.003106409
p_wrong:  0.000753558
Score:  0.541
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.983642811
p_ni:  0.016357189
Data Source:  BioPlex
NDUFA12
Tclin
Family:  Enzyme
Novelty:  0.04679316
p_int:  0.981631466
p_ni:  0.018368534
Score:  0.193
Data Source:  BioPlex,STRINGDB
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
p_int:  0.981478147
p_ni:  0.018519778
p_wrong:  0.000002075
Score:  0.177
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.979845765
p_ni:  0.020154233
p_wrong:  2e-9
Score:  0.33
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
97.8
basophil count
2
2
2
83.5
platelet count
2
2
2
76.1
alcohol consumption measurement
3
3
3
68.3
alcohol use disorder measurement
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
97.8
basophil count
2
83.5
platelet count
2
76.1
alcohol consumption measurement
3
68.3
alcohol use disorder measurement
1
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 6
VGNC:14410
451904
Macaque
polypeptide N-acetylgalactosaminyltransferase 6
695019
Mouse
MGI:1891640
207839
Rat
RGD:2319726
100361647
Dog
polypeptide N-acetylgalactosaminyltransferase 6
VGNC:41096
607787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polypeptide N-acetylgalactosaminyltransferase 6
Macaque
polypeptide N-acetylgalactosaminyltransferase 6
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 6
Publication Statistics
PubMed Score 28.14
PubMed score by year
PubTator Score 17.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title