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Tbio
CHST14
Carbohydrate sulfotransferase 14

Protein Classes
Protein Summary
Description
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306243
  • ENSP00000307297
  • ENSG00000169105

Symbol
  • D4ST1
  • ATCS
  • D4ST1
  • EDSMC1
  • HNK1ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.81
virus perturbation
0.72
cellular component
0.67
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.54   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.54   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
88
blood metabolite measurement
2
1
2
82.9
mean reticulocyte volume
1
1
1
66.8
intelligence
3
2
1
5.6
65.7
1
1
0
1.3
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
88
blood metabolite measurement
2
82.9
mean reticulocyte volume
1
66.8
intelligence
1
5.6
65.7
0
1.3
65.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919386
72136
Rat
RGD:1585023
691394
Dog
carbohydrate sulfotransferase 14
VGNC:54286
608435
Cow
carbohydrate sulfotransferase 14
VGNC:27342
511245
Pig
carbohydrate sulfotransferase 14
100520059
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
carbohydrate sulfotransferase 14
Cow
carbohydrate sulfotransferase 14
Pig
carbohydrate sulfotransferase 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NCH0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Chondroitin sulfate/dermatan sulfate metabolism (R-HSA-1793185)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective CHST14 causes EDS, musculocontractural type
Reactome
Dermatan sulfate biosynthesis
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate/dermatan sulfate metabolism
Defective CHST14 causes EDS, musculocontractural type
Dermatan sulfate biosynthesis
Disease
Diseases associated with glycosaminoglycan metabolism
Protein-Protein Interactions (67)
1 – 10 of 67
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999937039
p_ni:  0.000062958
p_wrong:  3e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.925632017
p_ni:  0.074367983
Score:  0.173
Data Source:  BioPlex,STRINGDB
FUT11
Tbio
Family:  Enzyme
Novelty:  0.16098097
p_int:  0.924964038
p_ni:  0.074296439
p_wrong:  0.000739522
Score:  0.576
Data Source:  BioPlex,STRINGDB
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.817876761
p_ni:  0.182123239
Score:  0.421
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.765647232
p_ni:  0.234352768
Score:  0.154
Data Source:  BioPlex,STRINGDB
DSE
Tbio
Family:  Enzyme
Novelty:  0.02945465
Score:  0.98
Data Source:  STRINGDB
CHST15
Tbio
Family:  Enzyme
Novelty:  0.03950241
Score:  0.978
Data Source:  STRINGDB
DCN
Tbio
Novelty:  0.00073027
Score:  0.94
Data Source:  STRINGDB
BGN
Tbio
Novelty:  0.00139486
Score:  0.93
Data Source:  STRINGDB
VCAN
Tbio
Novelty:  0.00110986
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  45.54

PubMed score by year
PubTator Score  23.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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