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Tchem
DAGLB
Sn1-specific diacylglycerol lipase beta

Protein Summary
Description
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297056
  • ENSP00000297056
  • ENSG00000164535
  • ENST00000425398
  • ENSP00000391171

Symbol
  • KCCR13L
  • DAGLBETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
metabolite
0.82
transcription factor perturbation
0.68
tissue sample
0.67
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.69   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
3
7
94.8
monocyte count
5
4
5
94.4
red blood cell distribution width
2
3
3
86.4
mean platelet volume
3
1
3
82.9
neutrophil percentage of leukocytes
2
2
2
72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
94.8
monocyte count
5
94.4
red blood cell distribution width
3
86.4
mean platelet volume
3
82.9
neutrophil percentage of leukocytes
2
72
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
diacylglycerol lipase beta
717799
Mouse
MGI:2442032
231871
Rat
RGD:1310193
304289
Dog
diacylglycerol lipase beta
VGNC:39765
479756
Horse
diacylglycerol lipase beta
VGNC:17002
100061701
Species
Name
OMA
EggNOG
Inparanoid
Macaque
diacylglycerol lipase beta
Mouse
Rat
Dog
diacylglycerol lipase beta
Horse
diacylglycerol lipase beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NCG7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (99)
Arachidonate production from DAG (R-HSA-426048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonate production from DAG
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Arachidonate production from DAG
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (46)
1 – 10 of 46
NCR3LG1
Tbio
Novelty: 0.02681936
p_int: 0.999317426
p_ni: 0.000682574
Data Source: BioPlex
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.997878546
p_ni: 0.002121453
Data Source: BioPlex
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.997329418
p_ni: 0.002669811
p_wrong: 7.7e-7
Data Source: BioPlex
VSIG1
Tbio
Novelty: 0.15442611
p_int: 0.997124055
p_ni: 0.002875945
Data Source: BioPlex
PCDHAC2
Tdark
Novelty: 0.28397695
p_int: 0.98719558
p_ni: 0.012804419
p_wrong: 1e-9
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.977422967
p_ni: 0.022577011
p_wrong: 2.2e-8
Data Source: BioPlex
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
p_int: 0.967109402
p_ni: 0.03289058
p_wrong: 1.8e-8
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.966739953
p_ni: 0.033260047
Data Source: BioPlex
RXFP1
Tchem
Family: GPCR
Novelty: 0.00580827
p_int: 0.949065549
p_ni: 0.05092076
p_wrong: 0.000013691
Data Source: BioPlex
CMTM8
Tbio
Novelty: 0.0953768
p_int: 0.945405558
p_ni: 0.054594391
p_wrong: 5.1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  27.69

PubMed score by year
PubTator Score  7.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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