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Tbio
NFATC2IP
NFATC2-interacting protein

Protein Summary
Description
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320805
  • ENSP00000324792
  • ENSG00000176953
  • ENST00000568148
  • ENSP00000454958

Symbol
  • NIP45
  • ESC2
  • NIP45
  • RAD60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
transcription factor perturbation
0.84
disease perturbation
0.79
microRNA
0.77
transcription factor binding site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (102)
1 – 10 of 102
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.999972004
p_ni:  0.000027682
p_wrong:  3.14e-7
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999801305
p_ni:  0.00019576
p_wrong:  0.000002935
Score:  0.539
Data Source:  BioPlex,STRINGDB
CHD8
Tbio
Family:  Epigenetic
Novelty:  0.01177693
p_int:  0.999222598
p_ni:  0.000777402
Score:  0.426
Data Source:  BioPlex,STRINGDB
ACTR6
Tbio
Novelty:  0.11005766
p_int:  0.999113585
p_ni:  0.000886415
Score:  0.817
Data Source:  BioPlex,STRINGDB
ELF2
Tbio
Family:  TF
Novelty:  0.01302604
p_int:  0.99882371
p_ni:  0.001176269
p_wrong:  2.1e-8
Data Source:  BioPlex
ZNHIT1
Tbio
Novelty:  0.00390514
p_int:  0.997382461
p_ni:  0.000110888
p_wrong:  0.002506651
Score:  0.82
Data Source:  BioPlex,STRINGDB
PDLIM5
Tbio
Novelty:  0.0040646
p_int:  0.996567499
p_ni:  0.003432501
Score:  0.542
Data Source:  BioPlex,STRINGDB
SRCAP
Tbio
Family:  Enzyme
Novelty:  0.02446238
p_int:  0.995296397
p_ni:  0.004703601
p_wrong:  2e-9
Score:  0.793
Data Source:  BioPlex,STRINGDB
VPS72
Tbio
Novelty:  0.00561093
p_int:  0.995104928
p_ni:  0.004894267
p_wrong:  8.05e-7
Score:  0.343
Data Source:  BioPlex,STRINGDB
RHEB
Tbio
Family:  Enzyme
Novelty:  0.00313935
p_int:  0.987911224
p_ni:  0.012088776
Score:  0.185
Data Source:  BioPlex,STRINGDB
Pathways (28)
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
miRNA regulation of prostate cancer signaling pathways
WikiPathways
miRNA regulation of prostate cancer signaling pathways
WikiPathways
miRNA regulation of prostate cancer signaling pathways
WikiPathways
EPO Receptor Signaling
WikiPathways
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Name
Explore in Pharos
Explore in Source
miRNA regulation of prostate cancer signaling pathways
miRNA regulation of prostate cancer signaling pathways
miRNA regulation of prostate cancer signaling pathways
EPO Receptor Signaling
Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
16
6
22
3.6
98.3
mathematical ability
3
2
3
91.4
intelligence
5
8
4
7
90.1
waist-hip ratio
3
2
3
86.8
self reported educational attainment
3
3
3
84.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
22
3.6
98.3
mathematical ability
3
91.4
intelligence
4
7
90.1
waist-hip ratio
3
86.8
self reported educational attainment
3
84.6
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T-cells 2 interacting protein
743214
Macaque
nuclear factor of activated T-cells 2 interacting protein
704878
Mouse
MGI:1329015
18020
Rat
RGD:1359096
308983
Dog
nuclear factor of activated T cells 2 interacting protein
VGNC:43768
100856245
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear factor of activated T-cells 2 interacting protein
Macaque
nuclear factor of activated T-cells 2 interacting protein
Mouse
Rat
Dog
nuclear factor of activated T cells 2 interacting protein
Publication Statistics
PubMed Score 38.04
PubMed score by year
PubTator Score 14.43
PubTator score by year