Tbio NFATC2IP NFATC2-interacting protein

Protein Summary

Description

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Uniprot Accession IDs

• Q8NCF5
• B7Z4G5
• Q66K34
• Q6NVK1
• Q8NFR2
• Q96ST9

Gene Name

• NFATC2IP

Ensembl ID

• ENST00000320805
• ENSP00000324792
• ENSG00000176953
• ENST00000568148
• ENSP00000454958

Symbol

• NIP45
• ESC2
• NIP45
• RAD60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
transcription factor perturbation	0.84
disease perturbation	0.79
microRNA	0.77
transcription factor binding site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.33   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 71   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.33   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0