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Tbio
MTMR14
Myotubularin-related protein 14

Protein Summary
Description
Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3. This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.[provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296003
  • ENSP00000296003
  • ENSG00000163719
  • ENST00000351233
  • ENSP00000334070
  • ENST00000353332
  • ENSP00000323462

Symbol
  • C3orf29
  • C3orf29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.71
histone modification site profile
0.7
tissue sample
0.69
transcription factor perturbation
0.68
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.7   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.7   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (92)
1 – 10 of 92
CHURC1
Tbio
Novelty:  0.05885372
p_int:  0.996234934
p_ni:  0.003765064
p_wrong:  1e-9
Data Source:  BioPlex
FAM90A1
Tdark
Novelty:  0.95155075
p_int:  0.9949988
p_ni:  0.005001199
p_wrong:  2e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.961305633
p_ni:  0.038694363
p_wrong:  4e-9
Data Source:  BioPlex
WDR54
Tdark
Novelty:  1.19807122
p_int:  0.855046937
p_ni:  0.144953063
Score:  0.189
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.844888667
p_ni:  0.155111301
p_wrong:  3.2e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
PDP1
Tbio
Family:  Enzyme
Novelty:  0.00442352
p_int:  0.776581531
p_ni:  0.223418139
p_wrong:  3.3e-7
Score:  0.253
Data Source:  BioPlex,STRINGDB
PIKFYVE
Tchem
Family:  Kinase
Novelty:  0.00441336
Score:  0.953
Data Source:  STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
Score:  0.92
Data Source:  STRINGDB
INPP4A
Tbio
Family:  Enzyme
Novelty:  0.03714963
Score:  0.918
Data Source:  STRINGDB
INPP4B
Tbio
Family:  Enzyme
Novelty:  0.02053228
Score:  0.908
Data Source:  STRINGDB
Pathways (15)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Metabolism
Metabolism of lipids
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 14
VGNC:2432
460149
Macaque
myotubularin-related protein 14
703936
Mouse
MGI:1916075
97287
Rat
RGD:1304842
312634
Dog
myotubularin related protein 14
VGNC:43482
484668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 14
Macaque
myotubularin-related protein 14
Mouse
Rat
Dog
myotubularin related protein 14
Publication Statistics
PubMed Score 15.70
PubMed score by year
PubTator Score 8.07
PubTator score by year