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Tbio
HJURP
Holliday junction recognition protein

Protein Summary
Description
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000411486
  • ENSP00000414109
  • ENSG00000123485
  • ENST00000432087
  • ENSP00000407208
  • ENST00000441687
  • ENSP00000401944

Symbol
  • FAKTS
  • FLEG1
  • URLC9
  • FAKTS
  • URLC9
  • hFLEG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.81
histone modification site profile
0.79
cellular component
0.71
tissue sample
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.36   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.36   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
CENPA
Tbio
Novelty:  0.00154245
p_int:  0.999939761
p_ni:  0.000060239
Score:  0.999
Data Source:  BioPlex,STRINGDB
DUS1L
Tbio
Family:  Enzyme
Novelty:  0.15534492
p_int:  0.993164779
p_ni:  0.002804583
p_wrong:  0.004030639
Score:  0.485
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.992144435
p_ni:  0.007855565
Score:  0.905
Data Source:  BioPlex,STRINGDB
TUBA3C
Tchem
Novelty:  0.0187396
p_int:  0.987700859
p_ni:  0.012299141
Data Source:  BioPlex
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.91790325
p_ni:  0.08209675
Score:  0.943
Data Source:  BioPlex,STRINGDB
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.872081388
p_ni:  0.003070214
p_wrong:  0.124848398
Score:  0.959
Data Source:  BioPlex,STRINGDB
LRRC46
Tdark
Novelty:  1.159245
p_int:  0.769115098
p_ni:  0.230816926
p_wrong:  0.000067975
Score:  0.163
Data Source:  BioPlex,STRINGDB
MIS18BP1
Tbio
Novelty:  0.05688807
Score:  0.997
Data Source:  STRINGDB
OIP5
Tbio
Novelty:  0.02546471
Score:  0.992
Data Source:  STRINGDB
CENPN
Tbio
Novelty:  0.06923443
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Chromosome Maintenance
Reactome
Deposition of new CENPA-containing nucleosomes at the centromere
Reactome
Nucleosome assembly
Name
Explore in Pharos
Explore in Source
Cell Cycle
Chromosome Maintenance
Deposition of new CENPA-containing nucleosomes at the centromere
Nucleosome assembly
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
16
55
108
100
blood metabolite measurement
1
2
8
95.6
serum metabolite measurement
2
2
10
92.6
6
4
0
1.1
91
metabolite measurement
1
1
1
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bilirubin measurement
108
100
blood metabolite measurement
8
95.6
serum metabolite measurement
10
92.6
0
1.1
91
metabolite measurement
1
86.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Holliday junction recognition protein
VGNC:1960
460034
Macaque
Holliday junction recognition protein
718180
Mouse
MGI:2685821
381280
Rat
RGD:1305846
316602
Dog
Holliday junction recognition protein
VGNC:41697
100684935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Holliday junction recognition protein
Macaque
Holliday junction recognition protein
Mouse
Rat
Dog
Holliday junction recognition protein
Publication Statistics
PubMed Score 54.36
PubMed score by year
PubTator Score 30.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title