Tbio HJURP Holliday junction recognition protein

Protein Summary

Description

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.

Uniprot Accession IDs

• Q8NCD3
• A8IRH5
• B4DWR0
• B4DZV4
• Q9BUT2
• Q9NSL8

Gene Name

• HJURP

Ensembl ID

• ENST00000411486
• ENSP00000414109
• ENSG00000123485
• ENST00000432087
• ENSP00000407208
• ENST00000441687
• ENSP00000401944

Symbol

• FAKTS
• FLEG1
• URLC9
• FAKTS
• URLC9
• hFLEG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.81
histone modification site profile	0.79
cellular component	0.71
tissue sample	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 126   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0