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Tbio
NECAP1
Adaptin ear-binding coat-associated protein 1

Protein Summary
Description
Involved in endocytosis. This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339754
  • ENSP00000341737
  • ENSG00000089818
  • ENST00000450991
  • ENSP00000401963
  • ENST00000639955
  • ENSP00000491067

Symbol
  • EIEE21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
disease perturbation
0.9
kinase perturbation
0.88
histone modification site profile
0.86
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
NECAP2
Tdark
Novelty:  0.4141034
p_int:  0.99987652
p_ni:  0.000107227
p_wrong:  0.000016253
Score:  0.985
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.958971603
p_ni:  0.041027342
p_wrong:  0.000001055
Data Source:  BioPlex
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.956613903
p_ni:  0.043386081
p_wrong:  1.6e-8
Score:  0.954
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.986
Data Source:  STRINGDB
FCHO1
Tbio
Novelty:  0.10512826
Score:  0.976
Data Source:  STRINGDB
FCHO2
Tbio
Novelty:  0.12302279
Score:  0.975
Data Source:  STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
Score:  0.968
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.967
Data Source:  STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.965
Data Source:  STRINGDB
AMPH
Tbio
Novelty:  0.00201043
Score:  0.959
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
94.7
neutrophil count
2
2
2
76.7
mean reticulocyte volume
1
1
1
67.7
mean corpuscular volume
1
1
1
55.2
monocyte percentage of leukocytes
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.7
neutrophil count
2
76.7
mean reticulocyte volume
1
67.7
mean corpuscular volume
1
55.2
monocyte percentage of leukocytes
1
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NECAP endocytosis associated 1
VGNC:5499
451821
Macaque
NECAP endocytosis associated 1
716035
Mouse
MGI:1914852
67602
Rat
RGD:1306053
312694
Dog
NECAP endocytosis associated 1
VGNC:43716
486705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NECAP endocytosis associated 1
Macaque
NECAP endocytosis associated 1
Mouse
Rat
Dog
NECAP endocytosis associated 1
Publication Statistics
PubMed Score 9.11
PubMed score by year
PubTator Score 7.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title